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Homeobox B1
HoxB1-Pbx1 heterodimer binding DNA 1b72.png
Cartoon diagram of a HOXB1–PBX1 heterodimer (violet) binding a DNA fragment (blue). Rendering based on PDB 1b72.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HOXB1 ; HCFP3; HOX2; HOX2I; Hox-2.9
External IDs OMIM142968 MGI96182 HomoloGene1615 GeneCards: HOXB1 Gene
RNA expression pattern
PBB GE HOXB1 208224 at tn.png
More reference expression data
Species Human Mouse
Entrez 3211 15407
Ensembl ENSG00000120094 ENSMUSG00000018973
UniProt P14653 P17919
RefSeq (mRNA) NM_002144 NM_008266
RefSeq (protein) NP_002135 NP_032292
Location (UCSC) Chr 17:
48.53 – 48.53 Mb
Chr 11:
96.37 – 96.37 Mb
PubMed search [1] [2]

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.[1][2][3]


This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.[3]


HOXB1 has been shown to interact with PBX1.[4][5]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB1 homeobox B1". 
  4. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. doi:10.1093/emboj/17.5.1434. PMC 1170491. PMID 9482740. 
  5. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell 96 (4): 587–97. doi:10.1016/S0092-8674(00)80662-5. PMID 10052460. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.