This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.
Giampaolo A, Acampora D, Zappavigna V et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID2570724.
Guazzi S, Pintonello ML, Viganò A, Boncinelli E (1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells.". J. Biol. Chem.273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID9556594.
Case SS, Huber P, Lloyd JA (2000). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.". DNA Cell Biol.18 (11): 805–17. doi:10.1089/104454999314809. PMID10595394.
Liu X, Zhang X (2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells.". Chin. J. Traumatol.5 (1): 12–5. PMID11835749.
Kosaki K, Kosaki R, Suzuki T et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes.". Teratology65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.
Segara D, Biankin AV, Kench JG et al. (2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia.". Clin. Cancer Res.11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID15867264.