HOXB3

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HOXB3
Identifiers
AliasesHOXB3, HOX2, HOX2G, Hox-2.7, homeobox B3
External IDsMGI: 96184 HomoloGene: 1617 GeneCards: HOXB3
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for HOXB3
Genomic location for HOXB3
Band17q21.32Start48,548,870 bp[1]
End48,604,912 bp[1]
RNA expression pattern
PBB GE HOXB3 208414 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002146
NM_001330322
NM_001330323

NM_001079869
NM_010458

RefSeq (protein)

NP_001317251
NP_001317252
NP_002137

NP_001073338
NP_034588

Location (UCSC)Chr 17: 48.55 – 48.6 MbChr 11: 96.32 – 96.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[5][6][7]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120093 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048763 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ a b "Entrez Gene: HOXB3 homeobox B3".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.