HOXB6

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Homeobox B6
Protein HOXB6 PDB 1ahd.png
PDB rendering based on 1ahd.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HOXB6 ; HOX2; HOX2B; HU-2; Hox-2.2
External IDs OMIM142961 MGI96187 HomoloGene7366 GeneCards: HOXB6 Gene
RNA expression pattern
PBB GE HOXB6 205366 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3216 15414
Ensembl ENSG00000108511 ENSMUSG00000000690
UniProt P17509 P09023
RefSeq (mRNA) NM_018952 NM_008269
RefSeq (protein) NP_061825 NP_032295
Location (UCSC) Chr 17:
48.6 – 48.6 Mb
Chr 11:
96.29 – 96.3 Mb
PubMed search [1] [2]

Homeobox protein Hox-B6 is a protein that in humans is encoded by the HOXB6 gene.[1][2][3]

Function[edit]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.[3]

During development[edit]

HOX B6 gene is only expressed in erythoid progenitor cells, which are the precursor to red blood cells used for transport of oxygen and carbon dioxide throughout the body. During development, the formation of the HOX gene factor happens in the first stages of fetal development, namely soon after the establishment of the mesoderm, which is the “middle layer” of the future embryo. However, HOX B6 is only expressed once the undifferentiated stem cells of the embryo distinguish themselves into the erythpoietic phase. The research has shown that HOX B6 is not expressed in hematopoietic stem cells located in the red bone marrow, which are the precursor cells to all types of blood cells, or primordial germ cells (PGCs), the precursor to cells passed on in each generation.[4] Since it is a transcriptional factor, HOX B6 regulates erythpoigenesis (red blood cell formation) using mRNA as the basis for certain protein productions. The specific gene factor for erytopoigenesis has relatively been unobserved in the scientific community, and no known diseases have been associated with a defect HOX B6 gene. However, it has been shown in correlation with major skeletal deformations.[5]

See also[edit]

References[edit]

  1. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXB6 homeobox B6". 
  4. ^ Zimmermann F, Rich IN (Apr 1997). "Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations". Blood 89 (8): 2723–35. PMID 9108390. 
  5. ^ Rancourt DE, Tsuzuki T, Capecchi MR (Jan 1995). "Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation". Genes & Development 9 (1): 108–22. PMID 7828847. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.