HOXB7

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HOXB7
Protein HOXB7 PDB 1ahd.png
Identifiers
Aliases HOXB7, HHO.C1, HOX2, HOX2C, Hox-2.3, homeobox B7
External IDs MGI: 96188 HomoloGene: 55828 GeneCards: HOXB7
RNA expression pattern
PBB GE HOXB7 204778 x at tn.png

PBB GE HOXB7 204779 s at tn.png

PBB GE HOXB7 216973 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004502

NM_010460

RefSeq (protein)

NP_004493.3

NP_034590.2

Location (UCSC) Chr 17: 48.61 – 48.63 Mb Chr 11: 96.29 – 96.29 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[3][4]

Function[edit]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[5]

Interactions[edit]

HOXB7 has been shown to interact with PBX1[6] and CREB-binding protein.[7]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  4. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  5. ^ "Entrez Gene: HOXB7 homeobox B7". 
  6. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. doi:10.1101/gad.9.6.663. PMID 7729685. 
  7. ^ Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene. 18 (27): 4007–14. doi:10.1038/sj.onc.1202776. PMID 10435624. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.