This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
Giampaolo A, Acampora D, Zappavigna V et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.". Differentiation40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID2570724.
Boncinelli E, Acampora D, Pannese M et al. (1990). "Organization of human class I homeobox genes.". Genome31 (2): 745–56. doi:10.1139/g89-133. PMID2576652.
Apiou F, Flagiello D, Cillo C et al. (1996). "Fine mapping of human HOX gene clusters.". Cytogenet. Cell Genet.73 (1–2): 114–5. doi:10.1159/000134320. PMID8646877.
Vider BZ, Zimber A, Hirsch D et al. (1997). "Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression". Biochem. Biophys. Res. Commun.232 (3): 742–8. doi:10.1006/bbrc.1997.6364. PMID9126347.
Knoepfler PS, Sykes DB, Pasillas M, Kamps MP (2001). "HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation". Oncogene20 (39): 5440–8. doi:10.1038/sj.onc.1204710. PMID11571641.