From Wikipedia, the free encyclopedia
Jump to: navigation, search
Homeobox C11
Symbols HOXC11 ; HOX3H
External IDs OMIM605559 MGI96193 HomoloGene130362 GeneCards: HOXC11 Gene
RNA expression pattern
PBB GE HOXC11 206745 at tn.png
More reference expression data
Species Human Mouse
Entrez 3227 109663
Ensembl ENSG00000123388 ENSMUSG00000001656
UniProt O43248 P31313
RefSeq (mRNA) NM_014212 NM_001024842
RefSeq (protein) NP_055027 NP_001020013
Location (UCSC) Chr 12:
53.97 – 53.98 Mb
Chr 15:
102.95 – 102.96 Mb
PubMed search [1] [2]

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.[3]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–553. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXC11 homeobox C11". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.