This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.
Apiou F, Flagiello D, Cillo C, et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet.73 (1–2): 114–115. doi:10.1159/000134320. PMID8646877.
Flagiello D, Gibaud A, Dutrillaux B, et al. (1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Lett.415 (3): 263–267. doi:10.1016/S0014-5793(97)01118-6. PMID9357979.
Mitchelmore C, Troelsen JT, Sjöström H, Norén O (1998). "The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription". J. Biol. Chem.273 (21): 13297–13306. doi:10.1074/jbc.273.21.13297. PMID9582375.
Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology65 (2): 50–62. doi:10.1002/tera.10009. PMID11857506.
Zhang X, Hamada J, Nishimoto A, et al. (2007). "HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells". J. Cell. Mol. Med.11 (2): 299–306. doi:10.1111/j.1582-4934.2007.00020.x. PMID17488478.