HOXC6

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HOXC6
Protein HOXC6 PDB 1ahd.png
Identifiers
Aliases HOXC6, CP25, HHO.C8, HOX3, HOX3C, homeobox C6
External IDs MGI: 96197 HomoloGene: 19533 GeneCards: 3223
RNA expression pattern
PBB GE HOXC6 206858 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153693
NM_004503

NM_010465

RefSeq (protein)

NP_004494.1
NP_710160.1

NP_034595.2

Location (UCSC) Chr 12: 53.99 – 54.03 Mb Chr 15: 103 – 103.01 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene.[3][4][5]

Function[edit]

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  4. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  5. ^ a b "Entrez Gene: HOXC6 homeobox C6". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.