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Homeobox C6
Protein HOXC6 PDB 1ahd.png
PDB rendering based on 1ahd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HOXC6 ; CP25; HHO.C8; HOX3; HOX3C
External IDs OMIM142972 MGI96197 HomoloGene19533 GeneCards: HOXC6 Gene
RNA expression pattern
PBB GE HOXC6 206858 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3223 15425
Ensembl ENSG00000197757 ENSMUSG00000001661
UniProt P09630 P10629
RefSeq (mRNA) NM_004503 NM_010465
RefSeq (protein) NP_004494 NP_034595
Location (UCSC) Chr 12:
53.99 – 54.03 Mb
Chr 15:
103 – 103.01 Mb
PubMed search [1] [2]

Homeobox protein Hox-C6 is a protein that in humans is encoded by the HOXC6 gene.[1][2][3]

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons.[3]

See also[edit]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  3. ^ a b "Entrez Gene: HOXC6 homeobox C6". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.