From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
AliasesHOXC8, HOX3, HOX3A, homeobox C8
External IDsOMIM: 142970 MGI: 96198 HomoloGene: 130642 GeneCards: HOXC8
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for HOXC8
Genomic location for HOXC8
Band12q13.13Start54,008,985 bp[1]
End54,012,769 bp[1]
RNA expression pattern
PBB GE HOXC8 221350 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 54.01 – 54.01 MbChr 15: 102.99 – 102.99 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.[5][6][7]


This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders.[7] HOXC8 was found to have activity in promoting nerve growth and its expression is dysregulated in patients suffering from neurofibromatosis type 1.[8]

See also[edit]


HOXC8 has been shown to interact with Mothers against decapentaplegic homolog 6[9] and Mothers against decapentaplegic homolog 1.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000037965 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001657 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ a b "Entrez Gene: HOXC8 homeobox C8".
  8. ^ Liu Y, Kang D, Li C, Xu G, Tan Y, Wang J (Jan 2014). "Microarray‑based identification of nerve growth‑promoting genes in neurofibromatosis type I". Mol Med Rep. 9 (1): 192–6. doi:10.3892/mmr.2013.1785. PMID 24213587.
  9. ^ Bai S, Shi X, Yang X, Cao X (March 2000). "Smad6 as a transcriptional corepressor". J. Biol. Chem. 275 (12): 8267–70. doi:10.1074/jbc.275.12.8267. PMID 10722652.
  10. ^ Shi X, Yang X, Chen D, Chang Z, Cao X (May 1999). "Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling". J. Biol. Chem. 274 (19): 13711–7. doi:10.1074/jbc.274.19.13711. PMID 10224145.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.