HOXD1

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HOXD1
Identifiers
AliasesHOXD1, HOX4, HOX4G, Hox-4.7, homeobox D1
External IDsMGI: 96201 HomoloGene: 7772 GeneCards: HOXD1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for HOXD1
Genomic location for HOXD1
Band2q31.1Start176,188,668 bp[1]
End176,190,907 bp[1]
RNA expression pattern
PBB GE HOXD1 205974 at fs.png

PBB GE HOXD1 205975 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024501

NM_010467

RefSeq (protein)

NP_078777

NP_034597

Location (UCSC)Chr 2: 176.19 – 176.19 MbChr 2: 74.76 – 74.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.[5][6][7]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128645 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042448 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  6. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  7. ^ a b "Entrez Gene: HOXD1 homeobox D1".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.