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Homeobox D10
Symbols HOXD10 ; HOX4; HOX4D; HOX4E; Hox-4.4
External IDs OMIM142984 MGI96202 HomoloGene1619 GeneCards: HOXD10 Gene
RNA expression pattern
PBB GE HOXD10 207373 at tn.png
More reference expression data
Species Human Mouse
Entrez 3236 15430
Ensembl ENSG00000128710 ENSMUSG00000050368
UniProt P28358 P28359
RefSeq (mRNA) NM_002148 NM_013554
RefSeq (protein) NP_002139 NP_038582
Location (UCSC) Chr 2:
176.11 – 176.12 Mb
Chr 2:
74.69 – 74.7 Mb
PubMed search [1] [2]

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.[1]


This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance[edit]

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.[1][citation needed]


The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.[2][3][4]

See also[edit]


  1. ^ a b "Entrez Gene: HOXD10 homeobox D10". 
  2. ^ Lund AH (2010). "miR-10 in development and cancer.". Cell Death Differ 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655. 
  3. ^ Ma L, Teruya-Feldstein J, Weinberg RA (2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer.". Nature 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713. 
  4. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007). "DNA methylation regulates MicroRNA expression.". Cancer Biol Ther 6 (8): 1284–8. PMID 17660710. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.