HOXD10

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HOXD10
Identifiers
Aliases HOXD10, HOX4, HOX4D, HOX4E, Hox-4.4, homeobox D10
External IDs MGI: 96202 HomoloGene: 1619 GeneCards: HOXD10
Genetically Related Diseases
amyotrophic lateral sclerosis[1]
RNA expression pattern
PBB GE HOXD10 207373 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002148

NM_013554

RefSeq (protein)

NP_002139.2

NP_038582.2

Location (UCSC) Chr 2: 176.11 – 176.12 Mb Chr 2: 74.69 – 74.7 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.[4]

Function[edit]

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance[edit]

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.[4][citation needed]

Regulation[edit]

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.[5][6][7]

See also[edit]

References[edit]

  1. ^ "Diseases that are genetically associated with HOXD10 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: HOXD10 homeobox D10". 
  5. ^ Lund AH (Feb 2010). "miR-10 in development and cancer". Cell Death and Differentiation. 17 (2): 209–14. doi:10.1038/cdd.2009.58. PMID 19461655. 
  6. ^ Ma L, Teruya-Feldstein J, Weinberg RA (Oct 2007). "Tumour invasion and metastasis initiated by microRNA-10b in breast cancer". Nature. 449 (7163): 682–8. doi:10.1038/nature06174. PMID 17898713. 
  7. ^ Han L, Witmer PD, Casey E, Valle D, Sukumar S (Aug 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. PMID 17660710. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.