HOXD3

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HOXD3
Identifiers
Aliases HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1, homeobox D3
External IDs MGI: 96207 HomoloGene: 5034 GeneCards: HOXD3
RNA expression pattern
PBB GE HOXD3 206601 s at tn.png

PBB GE HOXD3 206602 s at tn.png

PBB GE HOXD3 217076 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006898

NM_010468

RefSeq (protein)

NP_008829.3

NP_034598.2

Location (UCSC) Chr 2: 176.14 – 176.17 Mb Chr 2: 74.71 – 74.75 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.[3][4][5]

Function[edit]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146. 
  4. ^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. 
  5. ^ a b "Entrez Gene: HOXD3 homeobox D3". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.