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Heparanase 2 (inactive)
Symbols HPSE2 ; HPA2; HPR2; UFS; UFS1
External IDs OMIM613469 HomoloGene19680 GeneCards: HPSE2 Gene
RNA expression pattern
PBB GE HPSE2 220927 s at tn.png
More reference expression data
Species Human Mouse
Entrez 60495 545291
Ensembl ENSG00000172987 ENSMUSG00000074852
UniProt Q8WWQ2 B2RY83
RefSeq (mRNA) NM_001166244 NM_001081257
RefSeq (protein) NP_001159716 NP_001074726
Location (UCSC) Chr 10:
98.46 – 99.24 Mb
Chr 19:
42.79 – 43.39 Mb
PubMed search [1] [2]

Heparanase-2 is an enzyme that in humans is encoded by the HPSE2 gene.[1][2]

It may be associated with urofacial syndrome.[3]


  1. ^ McKenzie E, Tyson K, Stamps A, Smith P, Turner P, Barry R, Hircock M, Patel S, Barry E, Stubberfield C, Terrett J, Page M (Oct 2000). "Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member". Biochem Biophys Res Commun 276 (3): 1170–7. doi:10.1006/bbrc.2000.3586. PMID 11027606. 
  2. ^ "Entrez Gene: HPSE2 heparanase 2". 
  3. ^ Daly SB, Urquhart JE, Hilton E, et al. (June 2010). "Mutations in HPSE2 Cause Urofacial Syndrome". Am J Hum Genet 86 (6): 963–969. doi:10.1016/j.ajhg.2010.05.006. PMC 3032078. PMID 20560210. 

Further reading[edit]