HS2ST1

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HS2ST1
Identifiers
Aliases HS2ST1, dJ604K5.2, heparan sulfate 2-O-sulfotransferase 1
External IDs MGI: 1346049 HomoloGene: 8025 GeneCards: HS2ST1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_012262
NM_001134492

NM_011828

RefSeq (protein)

NP_001127964
NP_036394

NP_035958.3
NP_035958

Location (UCSC) Chr 1: 86.91 – 87.11 Mb Chr 3: 144.43 – 144.57 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.[3][4]

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes heparan sulfate 2-O-sulfotransferase, a member of the heparan sulfate biosynthetic enzyme family. This family member transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (Feb 1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484. 
  4. ^ a b "Entrez Gene: HS2ST1 heparan sulfate 2-O-sulfotransferase 1". 

Further reading[edit]