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  • 3-[2-[cyclobutylmethyl(2-phenylethyl)amino]ethyl]phenol
CAS Number
PubChem CID
Chemical and physical data
Molar mass309.453 g·mol−1
3D model (JSmol)
  • InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2

HS665 is a drug which acts as a potent and selective κ-opioid receptor agonist, and has analgesic effects in animal studies.[1][2][3][4]. HS665 is not an agonist for the mu receptor, leading to less potential for abuse.[5]


  1. ^ Spetea M, Berzetei-Gurske IP, Guerrieri E, Schmidhammer H (November 2012). "Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective κ opioid receptor agonist". Journal of Medicinal Chemistry. 55 (22): 10302–6. doi:10.1021/jm301258w. PMID 23134120.
  2. ^ Spetea M, Eans SO, Ganno ML, Lantero A, Mairegger M, Toll L, et al. (August 2017). "Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice". British Journal of Pharmacology. 174 (15): 2444–2456. doi:10.1111/bph.13854. PMID 28494108.
  3. ^ Erli F, Guerrieri E, Ben Haddou T, Lantero A, Mairegger M, Schmidhammer H, Spetea M (September 2017). "Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships". Journal of Medicinal Chemistry. 60 (17): 7579–7590. doi:10.1021/acs.jmedchem.7b00981. PMID 28825813.
  4. ^ Zhu L, Cui Z, Zhu Q, Zha X, Xu Y. "Novel Opioid Receptor Agonists with Reduced Morphine-like Side Effects". Mini Reviews in Medicinal Chemistry. 18 (19): 1603–1610. doi:10.2174/1389557518666180716124336. PMID 30009707.
  5. ^ Advokat, Claire D.; Comaty, Joseph E.; Julien, Robert M. (2019). Julien's Primer of Drug Action: A comprehensive guide to the actions, uses, and side effects of psychoactive drugs (14th ed.). New York: Worth Publishers. p. 564. ISBN 978-1-319-20054-1. {{cite book}}: |access-date= requires |url= (help)