HSD17B4

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HSD17B4
Protein HSD17B4 PDB 1ikt.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HSD17B4, DBP, MFE-2, MPF-2, PRLTS1, SDR8C1, hydroxysteroid (17-beta) dehydrogenase 4
External IDs MGI: 105089 HomoloGene: 358 GeneCards: 3295
RNA expression pattern
PBB GE HSD17B4 201413 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001292028
NM_000414
NM_001199291
NM_001199292
NM_001292027

NM_008292

RefSeq (protein)

NP_000405.1
NP_001186220.1
NP_001186221.1
NP_001278956.1
NP_001278957.1

NP_032318.2

Location (UCSC) Chr 5: 119.45 – 119.64 Mb Chr 18: 50.13 – 50.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene.[3][4][5]

The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase (Leenders et al., 1996; van Grunsven et al., 1998). Peroxisomal beta-oxidation of fatty acids, originally described by Lazarow and de Duve (1976), is catalyzed by 3 enzymes: acyl-CoA oxidase (see, e.g., ACOX1, MIM 609751); the 'D-bifunctional enzyme,' with enoyl-CoA-hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase (MIM 604054).

See also the L-bifunctional peroxisomal protein (EHHADH; MIM 607037). The D- and L-bifunctional proteins have different substrate specificities. The D-bifunctional protein catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids and also acts in shortening cholesterol for bile acid formation. In contrast, the L-specific bifunctional protein does not have the latter 2 activities (Jiang et al., 1997).[supplied by OMIM][5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Leenders F, Prescher G, Dolez V, Begue A, de Launoit Y, Adamski J (Mar 1997). "Assignment of human 17 beta-hydroxysteroid dehydrogenase IV to chromosome 5q2 by fluorescence in situ hybridization". Genomics. 37 (3): 403–4. doi:10.1006/geno.1996.0578. PMID 8938456. 
  4. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744free to read. PMID 19027726. 
  5. ^ a b "Entrez Gene: HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4". 

Further reading[edit]