From Wikipedia, the free encyclopedia
Jump to: navigation, search
Hydroxysteroid (17-beta) dehydrogenase 4
Protein HSD17B4 PDB 1ikt.png
PDB rendering based on 1ikt.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols HSD17B4 ; DBP; MFE-2; MPF-2; PRLTS1; SDR8C1
External IDs OMIM601860 MGI105089 HomoloGene358 ChEMBL: 5814 GeneCards: HSD17B4 Gene
EC number 1.1.1.n12,,
RNA expression pattern
PBB GE HSD17B4 201413 at tn.png
More reference expression data
Species Human Mouse
Entrez 3295 15488
Ensembl ENSG00000133835 ENSMUSG00000024507
UniProt P51659 P51660
RefSeq (mRNA) NM_000414 NM_008292
RefSeq (protein) NP_000405 NP_032318
Location (UCSC) Chr 5:
119.45 – 119.64 Mb
Chr 18:
50.13 – 50.2 Mb
PubMed search [1] [2]

Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene.[1][2][3]

The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase (Leenders et al., 1996; van Grunsven et al., 1998). Peroxisomal beta-oxidation of fatty acids, originally described by Lazarow and de Duve (1976), is catalyzed by 3 enzymes: acyl-CoA oxidase (see, e.g., ACOX1, MIM 609751); the 'D-bifunctional enzyme,' with enoyl-CoA-hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase (MIM 604054).

See also the L-bifunctional peroxisomal protein (EHHADH; MIM 607037). The D- and L-bifunctional proteins have different substrate specificities. The D-bifunctional protein catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids and also acts in shortening cholesterol for bile acid formation. In contrast, the L-specific bifunctional protein does not have the latter 2 activities (Jiang et al., 1997).[supplied by OMIM][3]

See also[edit]


  1. ^ Leenders F, Prescher G, Dolez V, Begue A, de Launoit Y, Adamski J (Mar 1997). "Assignment of human 17 beta-hydroxysteroid dehydrogenase IV to chromosome 5q2 by fluorescence in situ hybridization". Genomics 37 (3): 403–4. doi:10.1006/geno.1996.0578. PMID 8938456. 
  2. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact 178 (1-3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. 
  3. ^ a b "Entrez Gene: HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4". 

Further reading[edit]