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Protein HSD17B8 PDB 2pd6.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesHSD17B8, D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8
External IDsOMIM: 601417 MGI: 95911 HomoloGene: 56588 GeneCards: HSD17B8
EC number1.1.1.239
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HSD17B8
Genomic location for HSD17B8
Band6p21.32Start33,204,655 bp[1]
End33,206,831 bp[1]
RNA expression pattern
PBB GE HSD17B8 213540 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 33.2 – 33.21 MbChr 17: 34.03 – 34.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.[5][6][7]

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.[7]


  1. ^ a b c ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 GRCh38: Ensembl release 89: ENSG00000204228, ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073422 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics. 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499.
  6. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. ^ a b "Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8".

Further reading[edit]