From Wikipedia, the free encyclopedia
Jump to: navigation, search
Heat shock transcription factor 4
Symbols HSF4 ; CTM; CTRCT5
External IDs OMIM602438 MGI1347058 HomoloGene100128 GeneCards: HSF4 Gene
RNA expression pattern
PBB GE HSF4 210977 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3299 26386
Ensembl ENSG00000102878 ENSMUSG00000033249
UniProt Q9ULV5 Q9R0L1
RefSeq (mRNA) NM_001040667 NM_001256042
RefSeq (protein) NP_001035757 NP_001242971
Location (UCSC) Chr 16:
67.16 – 67.17 Mb
Chr 8:
105.27 – 105.28 Mb
PubMed search [1] [2]

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.[1][2][3][4]

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.[4]

See also[edit]


  1. ^ Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (Jan 1997). "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator". Mol Cell Biol 17 (1): 469–81. PMC 231772. PMID 8972228. 
  2. ^ Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A (Nov 1999). "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing". J Biol Chem 274 (39): 27845–56. doi:10.1074/jbc.274.39.27845. PMID 10488131. 
  3. ^ Bu L, Jin Y, Shi Y, Chu R, Ban A, Eiberg H, Andres L, Jiang H, Zheng G, Qian M, Cui B, Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X (Jun 2002). "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract". Nat Genet 31 (3): 276–8. doi:10.1038/ng921. PMID 12089525. 
  4. ^ a b "Entrez Gene: HSF4 heat shock transcription factor 4". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.