HSF4

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HSF4
Identifiers
Aliases HSF4, CTM, CTRCT5, heat shock transcription factor 4
External IDs MGI: 1347058 HomoloGene: 100128 GeneCards: HSF4
RNA expression pattern
PBB GE HSF4 210977 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001538
NM_001040667

NM_001256042
NM_001256044
NM_011939

RefSeq (protein)

NP_001035757.1
NP_001529.2

NP_001242971.1
NP_036069.1

Location (UCSC) Chr 16: 67.16 – 67.17 Mb Chr 8: 105.27 – 105.28 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.[3][4][5][6]

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.[6]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K (Jan 1997). "HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator". Mol Cell Biol. 17 (1): 469–81. PMC 231772Freely accessible. PMID 8972228. 
  4. ^ Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A (Nov 1999). "The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing". J Biol Chem. 274 (39): 27845–56. doi:10.1074/jbc.274.39.27845. PMID 10488131. 
  5. ^ Bu L, Jin Y, Shi Y, Chu R, Ban A, Eiberg H, Andres L, Jiang H, Zheng G, Qian M, Cui B, Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X (Jun 2002). "Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract". Nat Genet. 31 (3): 276–8. doi:10.1038/ng921. PMID 12089525. 
  6. ^ a b "Entrez Gene: HSF4 heat shock transcription factor 4". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.