From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases HSPB6, HEL55, Hsp20, PPP1R91, heat shock protein family B (small) member 6
External IDs MGI: 2685325 HomoloGene: 36931 GeneCards: HSPB6
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HSPB6
Genomic location for HSPB6
Band 19q13.12 Start 35,754,569 bp[1]
End 35,758,079 bp[1]
RNA expression pattern
PBB GE HSPB6 214767 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 35.75 – 35.76 Mb Chr 7: 30.55 – 30.56 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Heat shock protein beta-6 is a protein that in humans is encoded by the HSPB6 gene.[5][6][7]

HSPB6 also known as hsp20 is a 17-kDa member of the small heat shock family of proteins. HSPB6 was first identified in 1994 when it was isolated from rat and human skeletal muscle as a complex with HSPB1 (also known as HSP27) and HSPB5 (also known as αB-crystallin).[8]

HSPB6 is expressed in multiple tissues; however, HSPB6 is most highly and constitutively expressed in different types of muscle including vascular, airway, colonic, bladder, uterine smooth muscle, cardiac muscle and skeletal muscle. HSPB6 has specific functions for vasodilation, platelet function, and insulin resistance[9] and in smooth and cardiac muscle.[10][11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000004776 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036854 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kappe G, Franck E, Verschuure P, Boelens WC, Leunissen JA, de Jong WW (Jun 2003). "The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10". Cell Stress Chaperones. 8 (1): 53–61. doi:10.1379/1466-1268(2003)8<53:THGECS>2.0.CO;2. PMC 514853Freely accessible. PMID 12820654. 
  6. ^ Bukach OV, Seit-Nebi AS, Marston SB, Gusev NB (Jan 2004). "Some properties of human small heat shock protein Hsp20 (HspB6)". Eur J Biochem. 271 (2): 291–302. doi:10.1046/j.1432-1033.2003.03928.x. PMID 14717697. 
  7. ^ "Entrez Gene: HSPB6 heat shock protein, alpha-crystallin-related, B6". 
  8. ^ Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T (May 1994). "Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin". J. Biol. Chem. 269 (21): 15302–9. PMID 8195168. 
  9. ^ Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM (Jan 2010). "The small heat shock protein, HSPB6, in muscle function and disease". Cell Stress Chaperones. 15 (1): 1–11. doi:10.1007/s12192-009-0127-8. PMC 2866971Freely accessible. PMID 19568960. 
  10. ^ Salinthone S, Tyagi M, Gerthoffer WT (July 2008). "Small heat shock proteins in smooth muscle". Pharmacol. Ther. 119 (1): 44–54. doi:10.1016/j.pharmthera.2008.04.005. PMC 2581864Freely accessible. PMID 18579210. 
  11. ^ Fan GC, Chu G, Kranias EG (May 2005). "Hsp20 and its cardioprotection". Trends Cardiovasc. Med. 15 (4): 138–41. doi:10.1016/j.tcm.2005.05.004. PMID 16099377. 

Further reading[edit]