HTATSF1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
HTATSF1
Protein HTATSF1 PDB 2dit.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases HTATSF1, TAT-SF1, TATSF1, dJ196E23.2, HIV-1 Tat specific factor 1
External IDs MGI: 1919709 HomoloGene: 40950 GeneCards: HTATSF1
RNA expression pattern
PBB GE HTATSF1 202602 s at fs.png

PBB GE HTATSF1 202601 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001163280
NM_014500

NM_028242
NM_029371

RefSeq (protein)

NP_001156752
NP_055315

NP_082518.1
NP_083647.1
NP_082518
NP_083647

Location (UCSC) Chr X: 136.5 – 136.51 Mb Chr X: 57.05 – 57.07 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.[3][4]

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[supplied by OMIM][4]

Interactions[edit]

HTATSF1 has been shown to interact with SUPT5H[5] and GTF2F2.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Zhou Q, Sharp PA (Nov 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. doi:10.1126/science.274.5287.605. PMID 8849451. 
  4. ^ a b "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1". 
  5. ^ a b Kim, J B; Yamaguchi Y; Wada T; Handa H; Sharp P A (Sep 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. UNITED STATES. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN 0270-7306. PMC 84462Freely accessible. PMID 10454543. 

Further reading[edit]