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5-hydroxytryptamine (serotonin) receptor 3C, ionotropic
Symbol HTR3C
External IDs OMIM610121 HomoloGene50847 IUPHAR: 375 ChEMBL: 4795 GeneCards: HTR3C Gene
Species Human Mouse
Entrez 170572 n/a
Ensembl ENSG00000178084 n/a
UniProt Q8WXA8 n/a
RefSeq (mRNA) NM_130770 n/a
RefSeq (protein) NP_570126 n/a
Location (UCSC) Chr 3:
183.77 – 183.78 Mb
PubMed search [1] n/a

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene.[1][2][1] The protein encoded by this gene is a subunit of the 5-HT3 receptor.[2]


  1. ^ a b Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637. 
  2. ^ a b Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181. 

Further reading[edit]

  • Karnovsky AM, Gotow LF, McKinley DD et al. (2003). "A cluster of novel serotonin receptor 3-like genes on human chromosome 3.". Gene 319: 137–48. doi:10.1016/S0378-1119(03)00803-5. PMID 14597179. 
  • Fasching PA, Kollmannsberger B, Strissel PL et al. (2008). "Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.". J. Cancer Res. Clin. Oncol. 134 (10): 1079–86. doi:10.1007/s00432-008-0387-1. PMID 18389280. 
  • Ward MB, Kotasek D, McKinnon RA (2008). "Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy.". Pharmacogenomics 9 (8): 1027–33. doi:10.2217/14622416.9.8.1027. PMID 18681779. 

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