HYAL1

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HYAL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHYAL1, HYAL-1, LUCA1, NAT6, MPS9, hyaluronoglucosaminidase 1, hyaluronidase 1
External IDsMGI: 96298 HomoloGene: 5277 GeneCards: HYAL1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for HYAL1
Genomic location for HYAL1
Band3p21.31Start50,299,889 bp[1]
End50,312,381 bp[1]
RNA expression pattern
PBB GE HYAL1 210619 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_008317
NM_001331161

RefSeq (protein)

NP_149349
NP_695013
NP_695014
NP_695015
NP_695017

NP_001318090
NP_032343

Location (UCSC)Chr 3: 50.3 – 50.31 MbChr 9: 107.58 – 107.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hyaluronidase-1 is an enzyme that in humans is encoded by the HYAL1 gene.[5][6][7]

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114378 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010051 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Frost GI, Csoka AB, Wong T, Stern R (Aug 1997). "Purification, cloning, and expression of human plasma hyaluronidase". Biochem Biophys Res Commun. 236 (1): 10–5. doi:10.1006/bbrc.1997.6773. PMID 9223416.
  6. ^ Csoka AB, Frost GI, Wong T, Stern R (Jan 1998). "Purification and microsequencing of hyaluronidase isozymes from human urine". FEBS Lett. 417 (3): 307–10. doi:10.1016/S0014-5793(97)01309-4. PMID 9409739.
  7. ^ a b "Entrez Gene: HYAL1 hyaluronoglucosaminidase 1".

Further reading[edit]