HYAL3

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HYAL3
Identifiers
Aliases HYAL3, HYAL-3, LUCA-3, LUCA3, hyaluronoglucosaminidase 3
External IDs MGI: 1330288 HomoloGene: 2626 GeneCards: HYAL3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003549
NM_001200029
NM_001200030
NM_001200031
NM_001200032

NM_178020

RefSeq (protein)

NP_001186958
NP_001186959
NP_001186960
NP_001186961
NP_003540

NP_821139.2
NP_821139

Location (UCSC) Chr 3: 50.29 – 50.3 Mb Chr 9: 107.58 – 107.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene.[3][4]

This gene encodes a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. However, this protein has not yet been shown to have hyaluronidase activity. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Csoka AB, Scherer SW, Stern R (Nov 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31". Genomics. 60 (3): 356–61. doi:10.1006/geno.1999.5876. PMID 10493834. 
  4. ^ a b "Entrez Gene: HYAL3 hyaluronoglucosaminidase 3". 

Further reading[edit]