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Aliases HYOU1, GRP-170, Grp170, HSP12A, ORP-150, ORP150, hypoxia up-regulated 1
External IDs MGI: 108030 HomoloGene: 4658 GeneCards: HYOU1
RNA expression pattern
PBB GE HYOU1 200825 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 119.04 – 119.06 Mb Chr 9: 44.38 – 44.39 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Hypoxia up-regulated protein 1 is a protein that in humans is encoded by the HYOU1 gene.[3][4][5]

The protein encoded by this gene belongs to the heat shock protein 70 family. This gene has three mRNAs from the use of alternative transcription sites. A cis-acting segment is found at the 5' end of exon 1A which is involved in the stress-dependent induction. The transcript that begins with exon 1B is preferentially induced by hypoxia, resulting in the accumulation of this protein in the endoplasmic reticulum (ER). The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. There is also an alternative translation site of this gene which lacks the signal peptide. This signal peptide-lacking protein, is only 3 amino acids shorter than the mature protein in the ER, and it is thought to have a housekeeping function in the cytosol.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ikeda J, Kaneda S, Kuwabara K, Ogawa S, Kobayashi T, Matsumoto M, Yura T, Yanagi H (Feb 1997). "Cloning and expression of cDNA encoding the human 150 kDa oxygen-regulated protein, ORP150". Biochem Biophys Res Commun. 230 (1): 94–9. doi:10.1006/bbrc.1996.5890. PMID 9020069. 
  4. ^ Ozawa K, Kuwabara K, Tamatani M, Takatsuji K, Tsukamoto Y, Kaneda S, Yanagi H, Stern DM, Eguchi Y, Tsujimoto Y, Ogawa S, Tohyama M (Mar 1999). "150-kDa oxygen-regulated protein (ORP150) suppresses hypoxia-induced apoptotic cell death". J Biol Chem. 274 (10): 6397–404. doi:10.1074/jbc.274.10.6397. PMID 10037731. 
  5. ^ a b "Entrez Gene: HYOU1 hypoxia up-regulated 1". 

Further reading[edit]