|Born||John Hagan Pryce Bayley
13 February 1951 
|Thesis||Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (1979)|
|Doctoral advisor||Jeremy Knowles|
Bayley's research is largely based on the study and engineering of transmembrane pore-forming proteins, as well as interests in chemical signal transduction and biomolecular materials. He is the co-founder of Oxford Nanopore Technologies Ltd. Bayley's research includes work on the pore-forming protein alpha haemolysin engineered for sensing has been highly cited.
Following his PhD, Bayley completed postdoctoral research at Massachusetts Institute of Technology, Columbia University, and Texas A&M University. Bayley has been based at the University of Oxford since 2003 and is a fellow of Hertford College, Oxford.
Awards and honours
|“||Hagan Bayley's achievements lie at the interface between chemistry and biology. He has used protein chemistry, organic chemistry, and biophysics to explore the folding, assembly, and function of transmembrane channels and pores. These studies have led to the development of protein pores as "nanoreactors", with which both non-covalent and covalent chemistry of single molecules can be examined. Applications of this methodology have included host-guest interactions and step-by-step polymer growth. Based on this work, Bayley has developed "stochastic sensing," which has been shown with a wide variety of analytes to reveal both concentration and identity through single-molecule detection.||”|
- BAYLEY, Prof. (John) Hagan (Pryce). ukwhoswho.com. Who's Who. 2014 (online edition via Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc. (subscription required)
- Bayley, H.; Knowles, J. R. (1978). "Photogenerated reagents for membrane labeling. 2. Phenylcarbene and adamantylidene formed within the lipid bilayer". Biochemistry. 17 (12): 2420–2423. PMID 678520. doi:10.1021/bi00605a026.
- ETHOS: Electronic THeses Online Service via the British Library
- Branton, D.; Deamer, D. W.; Marziali, A.; Bayley, H.; Benner, S. A.; Butler, T.; Di Ventra, M.; Garaj, S.; Hibbs, A.; Huang, X.; Jovanovich, S. B.; Krstic, P. S.; Lindsay, S.; Ling, X. S.; Mastrangelo, C. H.; Meller, A.; Oliver, J. S.; Pershin, Y. V.; Ramsey, J. M.; Riehn, R.; Soni, G. V.; Tabard-Cossa, V.; Wanunu, M.; Wiggin, M.; Schloss, J. A. (2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology. 26 (10): 1146–1153. PMC . PMID 18846088. doi:10.1038/nbt.1495.
- http://royalsociety.org/people/hagan-bayley/ Hagan Bayley at the Royal Society
- http://bayley.chem.ox.ac.uk/ Bayley group at the University of Oxford
- http://research.chem.ox.ac.uk/hagan-bayley.aspx Hagan Bayley Research page
- Hagan Bayley's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
- Braha, O.; Braha, H.; Conlan, L. Q.; Cheley, S.; Bayley, S. (1999). "Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter". Nature. 398 (6729): 686–690. PMID 10227291. doi:10.1038/19491.
- Lou, H; Chen, M; Black, S. S.; Bushell, S. R.; Ceccarelli, M; Mach, T; Beis, K; Low, A. S.; Bamford, V. A.; Booth, I. R.; Bayley, H; Naismith, J. H. (2011). "Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. Coli". PLOS ONE. 6 (10): e25825. PMC . PMID 22053181. doi:10.1371/journal.pone.0025825.
- Bayley, Hagan (1979). Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (PhD thesis). Harvard University.
- Howorka, S.; Cheley, S.; Bayley, H. (2001). "Sequence-specific detection of individual DNA strands using engineered nanopores". Nature Biotechnology. 19 (7): 636–639. PMID 11433274. doi:10.1038/90236.
- Bayley, Hagan Profile at the University of Oxford Archived 17 January 2010 at the Wayback Machine.
- Song, L.; Hobaugh, M. R.; Shustak, C.; Cheley, S.; Bayley, H.; Gouaux, J. E. (1996). "Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore". Science. 274 (5294): 1859–1865. PMID 8943190. doi:10.1126/science.274.5294.1859.
- Hagan Bayley's publications indexed by Google Scholar
- Bayley, H.; Cremer, P. S. (2001). "Stochastic sensors inspired by biology". Nature. 413 (6852): 226–230. PMID 11557992. doi:10.1038/35093038.
- Bayley, Hagan Profile at Hertford College
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