Hagan Bayley

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Hagan Bayley
Born John Hagan Pryce Bayley
(1951-02-13) 13 February 1951 (age 66)[1]
Fields Chemical Biology
Alma mater
Thesis Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (1979)
Doctoral advisor Jeremy Knowles[2]
Doctoral students
  • Lai-Sheung Choi
  • William Hwang
  • Samantha Shanley
  • Shiksha Mantri
  • David Stoddart
  • Gabriel Villar[3]
Known for
Notable awards

John Hagan Pryce Bayley FRS (born 13 February 1951[1]) is a British scientist, who holds the position of Professor of Chemical Biology at the University of Oxford.[6][7][8][9][10]


Bayley was educated at The King's School, Chester,[1] Balliol College, Oxford and Harvard University, where he was awarded a PhD in 1979.[2][11]


Bayley's research is largely based on the study and engineering of transmembrane pore-forming proteins,[12] as well as interests in chemical signal transduction and biomolecular materials.[13] He is the co-founder of Oxford Nanopore Technologies Ltd. Bayley's research includes work on the pore-forming protein alpha haemolysin[14] engineered for sensing has been highly cited.[15]


Following his PhD, Bayley completed postdoctoral research at Massachusetts Institute of Technology, Columbia University, and Texas A&M University.[16] Bayley has been based at the University of Oxford since 2003 and is a fellow of Hertford College, Oxford.[17]

Awards and honours[edit]

Bayley was elected a Fellow of the Royal Society in 2011.[5] His nomination reads


  1. ^ a b c d BAYLEY, Prof. (John) Hagan (Pryce). ukwhoswho.com. Who's Who. 2014 (online edition via Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.  (subscription required)
  2. ^ a b Bayley, H.; Knowles, J. R. (1978). "Photogenerated reagents for membrane labeling. 2. Phenylcarbene and adamantylidene formed within the lipid bilayer". Biochemistry. 17 (12): 2420–2423. PMID 678520. doi:10.1021/bi00605a026. 
  3. ^ ETHOS: Electronic THeses Online Service via the British Library
  4. ^ Branton, D.; Deamer, D. W.; Marziali, A.; Bayley, H.; Benner, S. A.; Butler, T.; Di Ventra, M.; Garaj, S.; Hibbs, A.; Huang, X.; Jovanovich, S. B.; Krstic, P. S.; Lindsay, S.; Ling, X. S.; Mastrangelo, C. H.; Meller, A.; Oliver, J. S.; Pershin, Y. V.; Ramsey, J. M.; Riehn, R.; Soni, G. V.; Tabard-Cossa, V.; Wanunu, M.; Wiggin, M.; Schloss, J. A. (2008). "The potential and challenges of nanopore sequencing". Nature Biotechnology. 26 (10): 1146–1153. PMC 2683588Freely accessible. PMID 18846088. doi:10.1038/nbt.1495. 
  5. ^ a b c http://royalsociety.org/people/hagan-bayley/ Hagan Bayley at the Royal Society
  6. ^ http://bayley.chem.ox.ac.uk/ Bayley group at the University of Oxford
  7. ^ http://research.chem.ox.ac.uk/hagan-bayley.aspx Hagan Bayley Research page
  8. ^ Hagan Bayley's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  9. ^ Braha, O.; Braha, H.; Conlan, L. Q.; Cheley, S.; Bayley, S. (1999). "Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter". Nature. 398 (6729): 686–690. PMID 10227291. doi:10.1038/19491. 
  10. ^ Lou, H; Chen, M; Black, S. S.; Bushell, S. R.; Ceccarelli, M; Mach, T; Beis, K; Low, A. S.; Bamford, V. A.; Booth, I. R.; Bayley, H; Naismith, J. H. (2011). "Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. Coli". PLOS ONE. 6 (10): e25825. PMC 3203869Freely accessible. PMID 22053181. doi:10.1371/journal.pone.0025825. 
  11. ^ Bayley, Hagan (1979). Adamantylidene: A Hydrophobic, Photogenerated Reagent for the Characterization of Intrinsic Membrane Proteins (PhD thesis). Harvard University. 
  12. ^ Howorka, S.; Cheley, S.; Bayley, H. (2001). "Sequence-specific detection of individual DNA strands using engineered nanopores". Nature Biotechnology. 19 (7): 636–639. PMID 11433274. doi:10.1038/90236. 
  13. ^ Bayley, Hagan Profile at the University of Oxford Archived 17 January 2010 at the Wayback Machine.
  14. ^ Song, L.; Hobaugh, M. R.; Shustak, C.; Cheley, S.; Bayley, H.; Gouaux, J. E. (1996). "Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore". Science. 274 (5294): 1859–1865. PMID 8943190. doi:10.1126/science.274.5294.1859. 
  15. ^ Hagan Bayley's publications indexed by Google Scholar
  16. ^ Bayley, H.; Cremer, P. S. (2001). "Stochastic sensors inspired by biology". Nature. 413 (6852): 226–230. PMID 11557992. doi:10.1038/35093038. 
  17. ^ Bayley, Hagan Profile at Hertford College