Hand–Schüller–Christian disease

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Hand–Schüller–Christian disease
A patient with Hand-Schüller-Christian Disease
Classification and external resources
Specialty hematology
ICD-10 C96.5
ICD-9-CM 277.89
DiseasesDB 5906
MeSH D006646

Hand–Schüller–Christian disease is associated with multifocal Langerhans cell histiocytosis.

It is associated with a triad of exophthalmos, lytic bone lesions (often in the skull), and diabetes insipidus (from pituitary stalk infiltration).[1]

It is named for Alfred Hand, Artur Schüller, and Henry Asbury Christian.[2][3][4][5]

See also[edit]


  1. ^ Kimura T, Ota K, Shoji M, et al. (1990). "Hand-Schüller-Christian disease with occult diabetes insipidus, cardiac failure and renal dysfunction". Jpn. J. Med. 29 (4): 405–10. PMID 2148780. 
  2. ^ synd/551 at Who Named It?
  3. ^ A. Hand. Polyuria and tuberculosis. Proceedings of the Pathological Society of Philadelphia, 1893, 16: 282-284. Archives of Pediatrics, New York, 1893: 10: 673-675.
  4. ^ A. Schüller. Über eigenartige Schädeldefekte im Jugendalter («Landkartenschädel»). Fortschritte auf dem Gebiete der Röntgenstrahlen, 1915-1916; 23: 12-18.
  5. ^ H. Christian. Defects in membranous bones, exophthalmos, and diabetes insipidus; an unusual syndrome of dyspituitarism. In: Contributions to medical and biological research, dedicated to Sir William Osler. New York, P. B. Hoeber, 1919, 1: 390-401. Medical Clinics of North America, Philadelphia, PA., 1920; 3: 849-871.