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Handedness is a human attribute reflecting the unequal distribution of fine motor skill between the left and right hands.
Handedness may also refer to:
- Chirality, Greek for handedness, used to describe similar concepts in other fields:
- Orientation (vector space), an asymmetry that makes a reflection impossible to replicate by means of a simple rotation
- Handedness of screw threads, springs, or propellers, in mechanics and engineering
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