"Handle This" is the fourth and final single from the album All Killer No Filler by the Canadian rock band Sum 41. The single was only released in Germany and included the title song and live versions of "Motivation" and "Makes No Difference" as back-up tracks, on the CD single. Sum 41 former in-house manager and producer Greig Nori played guitar on the song and a music video was made for the song. The video was not released along with the single, and it is only released on the Does This Look Infected Too? EP.
A music video was made for the single, which can be found on the "Does This Look Infected Too?" EP. The video is similar to the "Over My Head (Better Off Dead)" video. It shows assorted backstage footage and concert clips of the band from Tokyo, Japan.