September 23, 1952|
Medical School Hanover
University of Münster
|Alma mater||University of Tübingen
University of Mainz
Philosophy of Mind
Bothe studied Philosophy and Medicine from 1973 until 1981 in Tübingen und Mainz, graduated 1978 in Philosophy with Magister Artium, later working for three years at the Max-Planck-Institute for Neurological Research in Cologne. He received his PhD in 1983 (thesis: Artificial Brain Abscess in Cats and Therapy with Antibiotics and Steroids).
He specialized in Neurosurgery and completed his residency training at Johannes Gutenberg-University in Mainz. After achieving habilitation in 1991 he taught at Hanover Medical School and worked together with Madjid Samii at Nordstadt Hospital in Hanover. In 1993 he obtained a tenured professor for Neurosurgery at Westfälische Wilhelms-University in Münster.
Bothe initiated and organized the 1st International Workshop on Neurobionics in 1992 and founded thereby the recent field of research on Neurobionics, which aims at substitution of impaired functions of brain and spinal cord by neurosurgical implantation of microelectronic systems. For that purpose he brought together an international consortium of scientists covering for mathematics, neuroinformatics, biological basic research, microsystems, and medicine.
In 1991 he launched the International Neurobionics Foundation together with Daniel Goeudevert, Madjid Samii, and other representatives of science, industry, and policy. From 1991 until 1995 he managed the foundation as executive director of the board. He developed microelectronic implants to treat blind patients suffering from damaged retina (with B. Fischer, J.W. Bartha, et al.), microelectronic therapy to manage urinary incontinence (with B. von Heyden), and paraplegia (with J. Holsheimer).
Alterations of personality traits (antisocial behaviour concomitant to impaired moral decision making) observable after deep brain stimulation of the subthalamic nucleus (for therapy of Parkinsonian patients) brought him to be engaged in the problem of determinism and free will from both the perspective of neuroscience, and philosophy of mind: He accounts for the conviction that there is merely limited causality on the relationsship between activity of the brain and phenomenological events of the 1st person perspective due to non-linearity of cerebral information processing and supported logically by Gödel's incompleteness theorems.
- Neurobionics - an interdisciplinary approach to substitute impaired functions of the human nervous system, Elsevier, Amsterdam, 1993 ISBN 0-444-89958-8
- Joined effort SOLARIS: visual prosthesis by selective stimulation of the optic nerve in patients with retinal diseases (1998): http://www.ifess.org/ifess98/Abstracts/list169.pdf
- Sacral neuromodulation for urinary retention (2001): http://www.psychosomaticmedicine.org/cgi/reprint/63/3/505
- Adaptive closed-loop implant for selective repair of bladder, sexual, and bowels function in paraplegic patients (1998). In: Brunelli (eds), Proceedings of International symposium on experimental spinal cord repair and regeneration, Studio Progress, Brescia (with J. Holsheimer et al.)
- Alterations of sociomoral judgement and glucose utilization in the frontomedial cortex induced by electrical stimulation of the subthalamic nucleus (STN) in Parkinsonian patients (2004): http://www.egms.de/de/meetings/dgnc2004/04dgnc0207.shtml
- Neurobionik - Zukunftsmedizin mit mikroelektronischen Implantaten (in German), Umschau, Frankfurt, 1998 (with M. Engel)
- Visual field with a resolution of 64 points by selective stimulation of the optic nerve, Zentralbl Neurochir, Suppl 1, 2001 (with B. Fischer and A. Brentrup)
- Transverse tripolar spinal cord stimulation, Neuromodulation 9, 2006 (with J.C. Oakley and F. Espinosa)
- Internationale Stiftung Neurobionik (International Neurobionics Foundation)