Haplogroup DE

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Haplogroup DE
Possible time of origin 65,000 (59,100–68,300) BP[1] 50,000-55,000 split between D and E, 70,000-75,000 split between CF and DE [2]
Possible place of origin Africa or Asia
Ancestor CT
Descendants D, E
Defining mutations M1/YAP, M145 = P205, M203, P144, P153, P165, P167, P183

Haplogroup DE is a human Y-chromosome DNA haplogroup. It is defined by the single nucleotide polymorphism (SNP) mutations, or UEPs, M1(YAP), M145(P205), M203, P144, P153, P165, P167, P183.[3]

DE is unique because it is distributed in several geographically-distinct clusters. Moreover, the paragroup DE* has been found mostly in West Africa, while one immediate subclade, haplogroup D, is normally found only in eastern and south Asia, and the other immediate subclade, haplogroup E, is common in North Africa, Europe and the Middle East.

The most well-known unique event polymorphism (UEP) that defines DE is the Y-chromosome Alu Polymorphism (YAP) YAP. The mutation was caused when a strand of DNA, known as Alu, inserted a copy of itself into the Y chromosome. Hence all Y chromosomes belonging to DE, D, E and their subclades are YAP-positive (YAP+). All Y chromosomes that belong to other haplogroups and subclades are YAP-negative (YAP-).

Haplogroup DE is an estimated 65,000 years old.[1]

Distribution[edit]

The subclades of DE continue to confound investigators trying to reconstruct the migration of humans because, while they are common in Africa and East Asia, they are also largely absent between these two regions. As the paragroup DE* is extremely rare, the majority of DE male lines fall into subclades of either D-M174 or E-M96. While D-M174 likely originated in Asia – the only place where it is now found,[1] E-M96 is more likely to have originated in East Africa.[4][5] However, a West Asian origin for E-M96 is considered possible by some scholars.[6] Some researchers have suggested that the exceptional rarity of DE lineages in India – a region considered important in the dispersal of modern humans – may be meaningful, because D-M174 and E-M96 have remained common in neighbouring areas.[7] It has been inferred that a deleterious mutation or mutations may have been responsible for the extinction of DE lineages in India.

DE* has most often been found amongst Nigerian males, albeit at a low frequency. In a 2003 study of over 8,000 men worldwide, five out of 1,247 Nigerian males have classified as DE*. The study's authors cautioned that the apparently "paraphyletic status of this haplogroup ... [may] be illusory... [because] the only genealogically meaningful ... age of a clade is the time to its most recent common ancestor", and this timeline was not well understood.[8] Nevertheless, in 2007, another West African example of DE* was reported – carried by a speaker of the Nalu language who was among 17 Y-DNA samples taken in Guinea Bissau. The sequence of this individual differed by one mutation from those of the Nigerian individuals, indicating common ancestry, although the relationship between the two lineages has not been determined.[9] In 2008, DE* was identified in two individuals from Tibet (two out of 594).[10] It remains possible that the above examples of DE* are divergent forms of E and/or D,[citation needed] or the result of a back mutation.[citation needed]

Origins[edit]

Most parsimonious phylogeny of YAP based on Underhill and Kivisild 2007[7]

Discovery[edit]

The YAP insertion was discovered by scientists led by Michael Hammer of the University of Arizona.[11] Between 1997 and 1998 Hammer published three articles relating to the origins of haplogroup DE.[12][13][14] These articles state that YAP insertion occurred in Asia. As recently as 2007, some studies such as Chandrasekar et al. 2007, cite the publications by Hammer when arguing for an Asian origin of the YAP insertion.[6]

The scenarios outlined by Hammer include an out of Africa migration over 100,000 years ago, the YAP+ insertion on an Asian Y-chromosome 55,000 years ago and a back migration of YAP+ from Asia to Africa 31,000 years ago by its subclade haplogroup E.[14] This analysis was based on the fact that older African lineages, such as haplogroups A and B, were YAP negative whereas the younger lineage, haplogroup E was YAP positive. Haplogroup D, which is YAP positive, was clearly an Asian lineage, being found only in East Asia with high frequencies in Japan and Tibet. Because the mutations that define haplogroup E were observed to be in the ancestral state in haplogroup D, and haplogroup D at 55kya, was considerably older than haplogroup E at 31kya, Hammer concluded that haplogroup E was a subclade of haplogroup D.[14]

Contemporary studies[edit]

In 2000 a number of scientists had started to reassess the hypothesis of an Asian origin of the YAP insertion. Underhill et al. 2000 identified the D-M174 mutation that defines haplogroup D. The M174 allele is found in the ancestral state in all African lineages including haplogroup E. The discovery of M174 mutation meant that haplogroup E could not be a subclade of haplogroup D. These findings effectively neutralized the argument of an Asian origin of the YAP+ based on the character state of the M40 and M96 mutations that define haplogroup E. According to Underhill et al. 2000, the M174 data alone would support an African origin of the YAP insertion.[15]

Further arguments were made supporting and African origin of the YAP in Underhill et al. 2001. The arguments for an African origin include.[4]

  1. Africa has the highest frequency of YAP(>80%). Whereas the YAP+ in Asia has a fairly restricted geographic distribution, mainly at low to moderate frequencies (average 9.6%) in East Asia.[10]
  2. It was claimed that there was no archaeological evidence of a back-migration to Africa, and at the time of writing that there was no unequivocal Y DNA, mitochondrial DNA or autosomal DNA evidence of a back migration to Africa.[4]
  3. Although Haplogroup C seems to have originated in Asia at a similar time to Haplogroup DE's origin, Haplogroup C shows no sign of back migration to Africa.

The African origin of the YAP+ is also supported by studies concerning haplogroup E. In Altheide and Hammer 1997, the authors argue that haplogroup E arose in Asia on an ancestral YAP+ allele before migrating back to Africa.[13] However some studies, such as Semino et al., indicate that the highest frequency and diversity of haplogroup E is in Africa, and Africa is the most likely place of origin of the haplogroup.[10][16]

The models supporting an African origin or an Asian origin of the YAP+ insertion both required the extinction of the ancestral YAP chromosome to explain the current distribution of the YAP+ polymorphism. Paragroup DE* possesses neither the mutations that define haplogroup D or haplogroup E. If paragroup DE* was found in one location but not the other, it would boost one theory of the other.[17] Haplogroup DE* has recently been found in Nigeria,[8] Guinea-Bissau[9] and also in Tibet.[10] The phylogenetic relationship of three DE* sequences has yet to be determined, but it is known that the Guinea Bissau sequences differ from the Nigerian sequences by at least one mutation.[9] Weale et al. state that the discovery of DE* among Nigerians pushes back the date for the most recent common ancestor (MRCA) of African YAP chromosomes. This, in his view, has the effect of reducing the time window through which a possible back migration from Asia to Africa could occur.[8]

Chandrasekhar et al. 2007, have argued for the Asian origin of the YAP+. They state,

The presence of the YAP insertion in Northeast Indian tribes and Andaman Islanders with haplogroup D suggests that some of the M168 chromosomes gave rise to the YAP insertion and M174 mutation in South Asia

They also argue that YAP+ migrated back to Africa with other Eurasian haplogroups. These include Haplogroup R1b1* (18-23kya), which has been observed with especially high frequency among the members of some peoples in northern Cameroon, and Haplogroup T (39-45 kya), which has been observed in low frequencies in Africa. Haplogroup E at 50kya is considerably older than these haplogroups and has been observed at frequencies of 80-92% in Africa.

In a press release concerning a study by Karafet et al. (2008), Michael Hammer, revised the dates for the origin Haplogroup DE from 55,000 years ago to 65,000 years ago. For haplogroup E, Hammer revised the dates from 31,000 years ago to 50,000 years ago. Hammer is also quoted as saying “The age of haplogroup DE is about 65,000 years, just a bit younger than the other major lineage to leave Africa, which is assumed to be about 70,000 years old,” in which he implies that haplogroup DE left Africa along with Haplogroup CF.[18]

Peter Underhill states that there will always be uncertainty regarding the precise origins of DNA sequence variants such as YAP because of a lack of knowledge concerning prehistoric demographics and population movements. However Underhill contends that with all the available information, the African origin of the YAP+ polymorphism is more parsimonious and more plausible than the Asian origin hypothesis.[7] Other authors who have published or co-published works in support of an African origin of the YAP+ include Luigi Luca Cavalli-Sforza,[15] Toomas Kivisild,[7] Spencer Wells,[17] Linda Stone and Paul F. Lurquin.[19]

Tree[edit]

This phylogenetic tree of para-haplogroup DE is based on the YCC 2008 tree[1] and subsequent published research.

  • DE (M1/YAP, M145 [P205], M203, P144, P153, P165, P167, P183)
    • D (M174, (021355))
    • E (SRY4064, M96, P29, P150, P152, P154, P155, P156, P162)


Evolutionary tree of human Y-chromosome DNA haplogroups [χ 1][χ 2]
"Y-chromosomal Adam"
A00 A0-T [χ 3]
A0 A1[χ 4]
A1a A1b
A1b1 BT
B CT
DE CF
D E C F
F1 F2 F3 GHIJK
G HIJK
H IJK
IJ K
I J LT [χ 5]  K2
L T NO [χ 6] K2b [χ 7]   K2c K2d K2e [χ 8]
N O K2b1 [χ 9]    P
M S [χ 10] Q R
  1. ^ Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809. 
  2. ^ International Society of Genetic Genealogy (ISOGG; 2015), Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)
  3. ^ Haplogroup A0-T is also known as A0'1'2'3'4.
  4. ^ Haplogroup A1 is also known as A1'2'3'4.
  5. ^ Haplogroup LT (L298/P326) is also known as Haplogroup K1.
  6. ^ Haplogroup NO (M214) is also known as Haplogroup K2a (although the present Haplogroup K2e was also previously known as "K2a").
  7. ^ Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.
  8. ^ Haplogroup K2e (K-M147) was previously known as "Haplogroup X" and "K2a" (but is a sibling subclade of the present K2a, also known as Haplogroup NO).
  9. ^ Haplogroup K2b1 (P397/P399) is similar to the former Haplogroup MS, but has a broader and more complex internal structure.
  10. ^ Haplogroup S (S-M230) was previously known as Haplogroup K5.

See also[edit]

References[edit]

  1. ^ a b c d Karafet TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, Hammer MF (2008). "New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree". Genome Research 18 (5): 830–8. doi:10.1101/gr.7172008. PMC 2336805. PMID 18385274. 
  2. ^ Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans, Nature 505, 87–91 (02 January 2014)
  3. ^ ISOGG reference webpage.
  4. ^ a b c Underhill (2001). "The case for an African rather than an Asian origin of the human Y-chromosome YAP insertion". Genetic, Linguistic and Archaeological Perspectives on Human Diversity in Southeast Asia. New Jersey: World Scientific. ISBN 981-02-4784-2. 
  5. ^ Cruciani F, La Fratta R, Santolamazza P, et al. (May 2004). "Phylogeographic analysis of haplogroup E3b (E-M215) y chromosomes reveals multiple migratory events within and out of Africa". Am. J. Hum. Genet. 74 (5): 1014–22. doi:10.1086/386294. PMC 1181964. PMID 15042509. 
  6. ^ a b Chandrasekar A, Saheb SY, Gangopadyaya P, et al. (2007). "YAP insertion signature in South Asia". Ann. Hum. Biol. 34 (5): 582–6. doi:10.1080/03014460701556262. PMID 17786594. 
  7. ^ a b c d Underhill PA, Kivisild T (2007). "Use of y chromosome and mitochondrial DNA population structure in tracing human migrations". Annu. Rev. Genet. 41: 539–64. doi:10.1146/annurev.genet.41.110306.130407. PMID 18076332. 
  8. ^ a b c Weale ME, Shah T, Jones AL, et al. (September 2003). "Rare deep-rooting Y chromosome lineages in humans: Lessons for Phylogeography". Genetics 165 (1): 229–34. PMC 1462739. PMID 14504230. 
  9. ^ a b c Rosa A, Ornelas C, Jobling MA, Brehm A, Villems R (2007). "Y-chromosomal diversity in the population of Guinea-Bissau: a multiethnic perspective". BMC Evol. Biol. 7: 124. doi:10.1186/1471-2148-7-124. PMC 1976131. PMID 17662131. 
  10. ^ a b c d Shi H, Zhong H, Peng Y, et al. (2008). "Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations". BMC Biol. 6: 45. doi:10.1186/1741-7007-6-45. PMC 2605740. PMID 18959782. 
  11. ^ Hammer MF (September 1994). "A recent insertion of an alu element on the Y chromosome is a useful marker for human population studies". Mol. Biol. Evol. 11 (5): 749–61. PMID 7968488. 
  12. ^ Hammer MF, Karafet T, Rasanayagam A, et al. (April 1998). "Out of Africa and back again: nested cladistic analysis of human Y chromosome variation". Mol. Biol. Evol. 15 (4): 427–41. doi:10.1093/oxfordjournals.molbev.a025939. PMID 9549093. 
  13. ^ a b Altheide TK, Hammer MF (August 1997). "Evidence for a possible Asian origin of YAP+ Y chromosomes". Am. J. Hum. Genet. 61 (2): 462–6. doi:10.1016/S0002-9297(07)64077-4. PMC 1715891. PMID 9311756. 
  14. ^ a b c Hammer MF, Spurdle AB, Karafet T, et al. (March 1997). "The geographic distribution of human Y chromosome variation". Genetics 145 (3): 787–805. PMC 1207863. PMID 9055088. 
  15. ^ a b Underhill; et al. (2000). "The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations" (PDF). Ann. Hum. Genet. 65 (Pt 1): 43–62. doi:10.1046/j.1469-1809.2001.6510043.x. PMID 11415522. 
  16. ^ Semino O, Magri C, Benuzzi G, et al. (May 2004). "Origin, diffusion, and differentiation of Y-chromosome haplogroups E and J: inferences on the neolithization of Europe and later migratory events in the Mediterranean area". Am. J. Hum. Genet. 74 (5): 1023–34. doi:10.1086/386295. PMC 1181965. PMID 15069642. 
  17. ^ a b Wells RS, Yuldasheva N, Ruzibakiev R, et al. (August 2001). "The Eurasian heartland: a continental perspective on Y-chromosome diversity". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10244–9. doi:10.1073/pnas.171305098. PMC 56946. PMID 11526236. 
  18. ^ Scientists reshape Y chromosome haplogroup tree gaining new insights into human ancestry
  19. ^ Stone, Linda; Paul F. Lurquin; Luigi Luca Cavalli-Sforza (2007). "Voyages, Prehistoric Human Expansions". Genes, Culture, and Human Evolution. Malden, MA: Blackwell. p. 185. ISBN 1-4051-5089-0. 

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