Haplogroup X (mtDNA)
|Possible time of origin||ca. 45,000–20,000 years ago|
|Defining mutations||73, 7028, 11719, 12705, 14766, 16189, 16223, 16278|
Haplogroup X arose from haplogroup N, roughly 30,000 years ago (just prior to or during the Last Glacial Maximum). It is in turn ancestral to subclades X2 and X1, which arose ca. 20,000 and ca. 12,000 years ago, respectively.
Overall, haplogroup X is found in around 2% of the population of Europe, the Middle East and North Africa. It is especially common, 14.3%, among the natives of Bahariya Oasis (Western Desert, Egypt. The X1 subclade is much less frequent, and is largely restricted to North Africa, the Horn of Africa and the Near East.
Subclade X2 appears to have undergone extensive population expansion and dispersal around or soon after the Last Glacial Maximum, roughly 20,000 years ago. It is more strongly represented in the Near East, the Caucasus, and Southern Europe and somewhat less strongly present in the rest of Europe, how ever the oldest Archeological site associated to X2 is Kenniwick Man Washington State a ancient ancestor of tribes with the Salish, Cree, and Sioux Nations. The highest concentrations are found in the Ojibway (Canada) (25%), Sioux (USA) (15%), Nuu-Chah-Nulth (12%), Georgia (8%), Orkney (Scotland) (7%), and amongst the Druze Assyrian community in Israel (27%). Subclades of X2 are not present in native South Americans.
Haplogroup X has been found in various other fossils that were analysed for ancient DNA, including specimens associated with the Alföld Linear Pottery (X2b-T226C, Garadna-Elkerülő út site 2, 1/1 or 100%), Linearbandkeramik (X2d1, Halberstadt-Sonntagsfeld, 1/22 or ~5%), and Iberia Chalcolithic (X2b, La Chabola de la Hechicera, 1/3 or 33%; X2b, El Sotillo, 1/3 or 33%; X2b, El Mirador Cave, 1/12 or ~8%) cultures. Haplogroup X has been found in ancient Assyria & Ancient Egyptian mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the late New Kingdom and Roman periods. Fossils excavated at the Late Neolithic site of Kelif el Boroud (Kehf el Baroud) in Morocco, which have been dated to around 5,000 years old, have also been found to carry the X2 subclade.
The greatest frequency of haplogroup X is observed in the Druze, a minority population in Israel, Jordan, Lebanon, and Syria, as much in X1 (16%) as in X2 (11%). The Druze also have much diversity of X lineages. This pattern of heterogeneous parental origins is consistent with Druze oral tradition. The Galilee Druze represent a population isolate, so their combination of a high frequency and diversity of X signifies a phylogenetic refugium, providing a sample snapshot of the genetic landscape of the Near East prior to the modern age.
Although it occurs only at a frequency of about 3% for the total current indigenous population of the Americas, it is a bigger haplogroup in northern North America, where among the Algonquian peoples it comprises up to 25% of mtDNA types. It is also present in lesser percentages to the west and south of this area—among the Sioux (15%), the Nuu-chah-nulth (11%–13%), the Navajo (7%), and the Yakama (5%). In South America, Haplotype X6 was present in the Tarahumara 1.8% (1/53) and Huichol 20% (3/15) X6 and X7 was also found in 12% in Yanomani people.
Unlike the four main Native American mtDNA haplogroups (A, B, C, D), X is not strongly associated with East Asia. The main occurrence of X in Asia discovered so far is in the Altai people in Siberia.
One theory of how the X Haplogroup ended up in North America is that the people carrying it migrated from central Asia along with haplogroups A, B, C, and D, from an ancestor from the Altai Region of Central Asia. Two sequences of haplogroup X2 were sampled further east of Altai among the Evenks of Central Siberia. These two sequences belong to X2* and X2b. It is uncertain if they represent a remnant of the migration of X2 through Siberia or a more recent input.
This relative absence of haplogroup X2 in Asia is one of the major factors used to support the Solutrean hypothesis during the early 2000s. The Solutrean hypothesis postulates that haplogroup X reached North America with a wave of European migration emerging from the Solutrean culture, roughly 20,000 years ago. a stone-age culture in south-western France and in Spain, by boat around the southern edge of the Arctic ice pack. Since the later 2000s and during the 2010s, evidence has turned against the Solutrean hypothesis, as no presence of mt-DNA ancestral to X2a has been found in Europe or the Near East. New World lineages X2a and X2g are not derived form the Old World lineages X2b, X2c, X2d, X2e, and X2f, indicating an early origin of the New World lineages "likely at the very beginning of their expansion and spread from the Near East". A 2008 study came to the conclusion that the presence of haplogroup X in the Americas does not support migration from Solutrean-period Europe. The lineage of haplogroup X in the Americas is not derived from a European subclade, but rather represent an independent subclade, labelled X2a. The X2a subclade has not been found in Eurasia, and has most likely arisen within the early Paleo-Indian population, at roughly 13,000 years ago. A basal variant of X2a was found in the Kennewick Man fossil (ca. 9,000 years ago).
This phylogenetic tree of haplogroup X subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation and subsequent published research.
|Wikimedia Commons has media related to Haplogroup X (mtDNA).|
- Human mitochondrial DNA haplogroups
- Indigenous American genetic studies
- Kennewick Man
- The Seven Daughters of Eve
Phylogenetic tree of human mitochondrial DNA (mtDNA) haplogroups
|Mitochondrial Eve (L)|
X is estimated at 31.8+12.8
−12.1 kya (95% CI) in: "Supplementary Materials, Document S1" in: Soares, Pedro; Ermini, Luca; Thomson, Noel; Mormina, Maru; Rito, Teresa; Röhl, Arne; Salas, Antonio; Oppenheimer, Stephen; Macaulay, Vincent; Richards, Martin B. (12 June 2009). "Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". American Journal of Human Genetics. 84 (6): 740–759. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.
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- Kujanová, Martina; Pereira, Luísa; Fernandes, Verónica; Pereira, Joana B.; Černý, Viktor (October 2009). "Near Eastern Neolithic genetic input in a small oasis of the Egyptian Western Desert". American Journal of Physical Anthropology. 140 (2): 336–346. doi:10.1002/ajpa.21078. PMID 19425100.
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- "The similarities in ages and geographical distributions for C4c and the previously analyzed X2a lineage provide support to the scenario of a dual origin for Paleo-Indians. Taking into account that C4c is deeply rooted in the Asian portion of the mtDNA phylogeny and is indubitably of Asian origin, the finding that C4c and X2a are characterized by parallel genetic histories definitively dismisses the controversial hypothesis of an Atlantic glacial entry route into North America. Hooshiar Kashani B, Perego UA, Olivieri A, Angerhofer N, Gandini F, Carossa V, Lancioni H, Semino O, Woodward SR, Achilli A, Torroni A (January 2012). "Mitochondrial haplogroup C4c: a rare lineage entering America through the ice-free corridor?". American Journal of Physical Anthropology. 147 (1): 35–39. doi:10.1002/ajpa.21614. PMID 22024980.
- X2a is dated 12.8+7.1
−6.7 kya in Soares et al. (2009).
- "X2a has not been found anywhere in Eurasia, and phylogeography gives us no compelling reason to think it is more likely to come from Europe than from Siberia. Furthermore, analysis of the complete genome of Kennewick Man, who belongs to the most basal lineage of X2a yet identified, gives no indication of recent European ancestry and moves the location of the deepest branch of X2a to the West Coast, consistent with X2a belonging to the same ancestral population as the other founder mitochondrial haplogroups. Nor have any high-resolution studies of genome-wide data from Native American populations yielded any evidence of Pleistocene European ancestry or trans-Atlantic gene flow." Raff, Jennifer A.; Bolnick, Deborah A (2015). "Does Mitochondrial Haplogroup X Indicate Ancient Trans-Atlantic Migration to the Americas? A Critical Re-Evaluation". PaleoAmerica. 1 (4): 297–304. doi:10.1179/2055556315Z.00000000040.
- Mannis van Oven's – mtDNA subtree N
- Haplogroup X
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