The hotel traded under the name 'The Star and Garter' in the 18th century. The hotel was purchased in the 1830s by William Boyton and became known as 'Boyton's Hotel'. In the 1870s the hotel was purchased by Miss Eliza J. Hayes and thus became known as Hayes' Commercial and Family Hotel.
On 1 November 1884, a group of Irishmen gathered in the hotel billiard room to formulate a plan and establish an organisation to foster and preserve Ireland's unique games and athletic pastimes. And so was founded one of the world's greatest amateur associations, the GAA. The architects and founding members were Michael Cusack, Maurice Davin, Joseph Bracken, Thomas St George McCarthy, P.J. Ryan of Tipperary, John Wise-Power, and John McKay. On 18 July 1974 the Ladies' Gaelic Football Association was also formed at hotel. 
In April 2013, Hayes' Hotel went into receivership. The hotel was to remain open following the appointment of receivers, however they didn't offer room sales.
In October 2014, Fethard native Jack Halley took ownership of the Hotel, buying it at auction for €650,000.
- "Hayes Hotel Official Website". Hayeshotel.ie. Archived from the original on 2009-12-13. Retrieved 2010-01-05.
- "GAA mark 125th anniversary". RTÉ Sport. 2009-11-01. Archived from the original on 2010-01-05. Retrieved 2010-01-05.
- "History – The Beginning". ladiesgaelic.ie. Retrieved 21 October 2019.
- "There's only one Munster Hurling Final - one of the mind". Irish Times. 2009-07-08. Retrieved 2010-01-05.
- "Receivers appointed to Hayes' Hotel". Hogan Stand. 25 April 2013. Retrieved 30 October 2013.
- "Tipperary man buys piece of GAA history in Hayes Hotel". Irish Independent. 17 September 2015. Retrieved 19 August 2015.