The song was remixed by Canadian DJA-Trak and later by an online American artist named JVH-C, which has been the most notable and popular remix of the song. The latter has been used in Internet memes extensively, notably meme remixes.
The music video was directed by Richard Ayoade. It features the band playing in a (presumably) underground venue when a dancing werewolf (whose dancing is reminiscent of Michael Jackson) appears on stage. A light flashes halfway through the music video and the werewolf transforms. He then proceeds to chase after the audience and kills most of them. The video then ends with the band having been murdered while Karen O continues singing, her head severed from her body. The music video contains some mockery of horror in general; instead of blood, there is red glitter and confetti and Karen O keeps singing while decapitated. In the UK, there are two different versions of this video, the second replacing the violent conclusion with repeated clips from the previous section of the video, but it shows the confetti falling onto the band.
It was nominated for a VMA for "Breakthrough Video".
The A-Trak remix of the song was also featured in the 2012 film Project X and 2015 film Goosebumps.
The Kid Kamillion edit of this song was featured in Diplo's Sway in the Morning trap mix.
The Little Vampire remix of the song appears in the game Gran Turismo 5.
On 23 May 2015, a remix of the song was made by American SoundCloud artist JVH-C, which notably utilizes the lyric "dance 'til you're dead" multiple times throughout the track. It is currently the most recognized remix and has been used in meme remixes, usually accompanied by a dancing dog.
The song was used in the 2017 Netflix Original Series Atypical.