|Minister of State for Health|
July 2005 – January 2006
|Minister of Environment|
January 2006 – January 2007
|Preceded by||Iyorchia Ayu|
|Minister of Environment and Housing|
January 2007 – May 2007
|Preceded by||Rahman Mimiko (Housing)|
|Succeeded by||Halima Tayo Alao|
|Senator for Akwa Ibom South|
April 2011 – May 2015
|Preceded by||Eme Ufot Ekaette|
|Born||23 November 1949|
Helen U. Esuene (born 23 November 1949) is a former Nigerian civil servant who was appointed Minister of State for Health, and later Minister of Environment and Housing in the Cabinet of President Olusegun Obasanjo between 2005 and 2007.
Helen Esuene took a course in Confidential Secretaryship and Office Management at the Federal Training Centre in Kaduna and started her civil service career as a confidential secretary. Later she did a distance course from the University of Leicester and obtained Msc in Finance. Shortly after she married the former military governor of the old Cross River State, Chief Udokaha Esuene, who died in 1996. They had two girls and three boys. She went into business, starting with human resource management for Mobil Producing. Later she started what became Villa Marina Hotel in Eket, opening in 2000. 
Esuene was appointed Minister of State for Health in July 2005. She was appointed Minister of Environment in January 2006. After a cabinet reshuffle in January 2007, Esuene was given an expanded portfolio as Minister of Environment and Housing. She left office in May 2009 at the end of the Obasanjo administration.
- "Helen Udoakaha Esuene". Ring For Change. Retrieved 11 December 2012.
- Nseobong Okon-Ekong (12 December 2009). "Helen Esuene Emerging From the Shadow of a Famous Husband". ThisDay. Retrieved 2010-02-24.
- "As Obasanjo Reshuffles Cabinet... Ministers Under Probe for Corruption". BNW News. July 14, 2005. Retrieved 2010-02-24.
- KABIRU YUSUF (January 11, 2007). "Obasanjo reshuffles cabinet...Swears-in 6 new ministers". Daily Triumph. Retrieved 2010-02-24.
- EMMANUEL CHIDIOGO (April 11, 2011). "PDP sweeps Akwa-Ibom". Daily Times. Retrieved 2011-04-21.