A hemangioma or haemangioma is a usually benign vascular tumor derived from blood vessel cell types. The most common form is infantile hemangioma, known colloquially as a "strawberry mark", most commonly seen on the skin at birth or in the first weeks of life. A hemangioma can occur anywhere on the body, but most commonly appears on the face, scalp, chest or back. Treatment of a hemangioma is usually unnecessary unless the nodule interferes with vision or breathing, or in rare cases of internal hemangiomas causes or contributes to other medical problems.
Hemangiomas are benign (noncancerous) vascular tumors, and many different types occur. The correct terminology for these hemangioma types is constantly being updated by the International Society for the Study of Vascular Anomalies (ISSVA). The most common are infantile hemangiomas, and congenital hemangiomas.
Infantile hemangiomas are the most common benign tumor found in children. They are made up of blood vessels, often called strawberry marks, and are more common in girls than in boys. They usually appear on the skin of infants who are 4–6 weeks old. They tend to either grow quickly for up to a few months, and then shrink or involute without further problem, however some can ulcerate and form scabs which can be painful. Depending on their location and size, they may also be disfiguring.
Rarely, they may be related to disorders of the central nervous system or spine. They may also occur in the internal organs of the body, such as the liver, airway or brain.
The color of the hemangioma depends on how deep it is in the skin: superficial (near the skin's surface) hemangiomas tend to be bright red; deep (furthest from the skin's surface) hemangiomas are often blue or purple; mixed hemangiomas may have colors of both superficial and deep.
Congenital hemangiomas are present on the skin at birth, unlike infantile hemangiomas, which appear later. They are fully formed at birth, meaning that they do not grow after a child is born, as infantile hemangiomas do. They are less common than infantile hemangiomas. Congenital hemangiomas can be coloured from pink to blue.
Congenital hemangiomas are classified according to whether they shrink and go away, or do not shrink, and do not go away, or partially shrink. Those that shrink are known as rapidly involuting congenital hemangiomas (RICH) and go away quickly. Those that do not shrink, and remain are known as noninvoluting congenital hemangiomas (NICH). Others that partially shrink are known as partially involuting congenital hemangiomas (PICH).
Other types of hemangioma include cavernous hemangiomas such as cavernous hemangioma of the liver.
Cavernous liver hemangioma
A cavernous liver hemangioma or hepatic hemangioma is a benign tumour of the liver composed of hepatic endothelial cells. It is the most common liver tumour, and is usually asymptomatic and diagnosed incidentally on radiological imaging. Liver hemangiomas are thought to be congenital in origin. Several subtypes exist, including the giant hepatic hemangioma, which can cause significant complications.
Drug-induced hemangiomas are reported side-effects for some drugs in nonclinical toxicology animal models, studying carcinogenesis. For example, hemangiomas of the mesenteric lymph node were increased significantly at 700 mg/kg/day of Empagliflozin in male rats, or approximately 42 times the exposure from a 25 mg clinical dose.  It is inferred from nonclinical animal studies that some drugs can also produce hemangiomos in humans, and careful dosing during therapeutic drug design can ensure their safe use.
Diagnosis is usually clinical and tests are not necessary.
Hemangiomas usually fade gradually over time, and most do not require treatment. Therapeutic options can have side effects and are avoided if possible. However, hemangiomas that may be disfiguring or that are located at sites that can cause impairment (eyelids, airway) are often treated, typically with pharmacotherapy first. Management options may include:
- Beta blockers
- Laser surgery
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