Heme ligase
| Heme ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.99.1.8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Heme ligase (EC 4.99.1.8, heme detoxification protein, HDP, hemozoin synthase) is an enzyme with systematic name Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming).[1] This enzyme catalyses the following chemical reaction
- 2 ferriprotoporphyrin IX beta-hematin
This heme detoxifying enzyme is found in Plasmodium parasites.
References
- ^ Jani, D., Nagarkatti, R., Beatty, W., Angel, R., Slebodnick, C., Andersen, J., Kumar, S. and Rathore, D. (2008). "HDP-a novel heme detoxification protein from the malaria parasite". PLoS Pathog. 4: e1000053–e1000053. doi:10.1371/journal.ppat.1000053. PMC 2291572. PMID 18437218.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
External links
- Heme+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)