He married in 1899 and made numerous portraits of his wife, Jeanne, and their family. In 1902, Manguin had his first exhibition at the Salon des Indépendants and d'Automne. Many of his paintings were of Mediterranean landscapes; these represented the height of his career as a Fauve artist.
In 1920, Manguin exhibited at the Gallery Marcel Bernheim together with Ottmann, Tirman, Alexandre-Paul Canu and others.
He traveled extensively with Albert Marquet throughout Southern Europe. In 1949, Manguin left Paris to settle in Saint-Tropez, where he died soon after, on 25 September 1949.