Heparin cofactor II

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SERPIND1
Protein SERPIND1 PDB 1jmj.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SERPIND1, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10, serpin family D member 1
External IDs OMIM: 142360 MGI: 96051 HomoloGene: 36018 GeneCards: SERPIND1
RNA expression pattern
PBB GE SERPIND1 205576 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000185

NM_008223
NM_001331047

RefSeq (protein)

NP_000176

NP_032249.3
NP_001317976
NP_032249

Location (UCSC) Chr 22: 20.77 – 20.79 Mb Chr 16: 17.33 – 17.34 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a cofactor for heparin and dermatan sulfate ("minor antithrombin").[3]

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.[3] Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state.

References[edit]

Further reading[edit]

External links[edit]