Heparosan-N-sulfate-glucuronate 5-epimerase

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Heparosan-N-sulfate-glucuronate 5-epimerase
6i01.jpg
Identifiers
EC number5.1.3.17
CAS number112567-86-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Heparosan-N-sulfate-glucuronate 5-epimerase (EC 5.1.3.17, heparosan epimerase, heparosan-N-sulfate-D-glucuronosyl 5-epimerase, C-5 uronosyl epimerase, polyglucuronate epimerase, D-glucuronyl C-5 epimerase, poly[(1,4)-beta-D-glucuronosyl-(1,4)-N-sulfo-alpha-D-glucosaminyl] glucurono-5-epimerase) is an enzyme with systematic name poly((1->4)-beta-D-glucuronosyl-(1->4)-N-sulfo-alpha-D-glucosaminyl) glucurono-5-epimerase.[1] This enzyme catalyses the following chemical reaction

heparosan-N-sulfate D-glucuronate heparosan-N-sulfate L-iduronate

This enzyme acts on D-glucuronosyl residues adjacent to sulfated D-glucosamine units in the heparin precursor.

See also[edit]

References[edit]

  1. ^ Bäckström G, Höök M, Lindahl U, Feingold DS, Malmström A, Rodén L, Jacobsson I (April 1979). "Biosynthesis of heparin. Assay and properties of the microsomal uronosyl C-5 epimerase". The Journal of Biological Chemistry. 254 (8): 2975–82. PMID 107165.

External links[edit]