Hepatic fructokinase

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ketohexokinase (fructokinase)
Identifiers
SymbolKHK
Entrez3795
HUGO6315
OMIM229800
RefSeqNM_006488
UniProtP50053
Other data
EC number2.7.1.3
LocusChr. 2 p23.3-23.2
Ketohexokinase
Identifiers
EC number2.7.1.3
CAS number9030-50-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.


ATP + Fru    ADP + F1P
ATP + D-fructose → ADP + D-fructose-1-phosphate[1]

Pathology[edit]

A deficiency is associated with essential fructosuria.

References[edit]

  1. ^ Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. PMC 1152585. PMID 2996495.

External links[edit]