Hepatic fructokinase

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ketohexokinase (fructokinase)
Symbol KHK
Entrez 3795
HUGO 6315
OMIM 229800
RefSeq NM_006488
UniProt P50053
Other data
EC number
Locus Chr. 2 p23.3-23.2

Hepatic fructokinase (or ketohexokinase ) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.

ATP + Fru  \longrightarrow  ADP + F1P
ATP + D-fructose → ADP + D-fructose-1-phosphate[1]


A deficiency is associated with essential fructosuria.


  1. ^ Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. PMC 1152585. PMID 2996495. 

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