Hepatitis B virus PRE alpha

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Hepatitis B virus PRE alpha
Type: Cis-reg;
2° structure: Published; PMID 9776740[1]
Seed alignment: PMID 9776740[1]
Avg length: 30 nucleotides
Avg identity: 00%

The Hepatitis B virus PREalpha (HBV PREalpha) is an RNA structure that is shown to play a role in nuclear export of HBV mRNAs.

HBV PREalpha consists of a 30 nt stem-loop, with a 5 nt apical loop. The conserved stem-loop was predicted within the HBV PRE sequence and confirmed by mutagenesis.[1] The Rfam structure is based on a covariation model and is consistent with its solution structure.[2]

The exact role of this structure in nuclear export has not yet been determined [3]

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References[edit]

  1. ^ a b c Smith Gj, 3rd; Donello, JE; Lück, R; Steger, G; Hope, TJ (1998). "The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for function". Nucleic Acids Research. 26 (21): 4818–27. doi:10.1093/nar/26.21.4818. PMC 147918free to read. PMID 9776740. 
  2. ^ Schwalbe, M; Ohlenschläger, O; Marchanka, A; Ramachandran, R; Häfner, S; Heise, T; Görlach, M (March 2008). "Solution structure of stem-loop alpha of the hepatitis B virus post-transcriptional regulatory element". Nucleic Acids Research. 36 (5): 1681–9. doi:10.1093/nar/gkn006. PMC 2275152free to read. PMID 18263618. 
  3. ^ Chen, A; Panjaworayan T-Thienprasert, N; Brown, CM (7 July 2014). "Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus.". World Journal of Gastroenterology : WJG. 20 (25): 7993–8004. doi:10.3748/wjg.v20.i25.7993. PMID 25009369. 

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