Hepburn may refer to:
- Hepburn romanization, a system for the romanization of Japanese
- Shire of Hepburn, a local government area in Victoria
- Hepburn Springs, Victoria, a resort town in Victoria
- Hepburn, Saskatchewan, a small farming and college community
- United Kingdom
- United States
- Hepburn, Indiana, an unincorporated community
- Hepburn, Iowa, a city in Page County
- Hepburn, Ohio, an unincorporated community in Hardin County
- Hepburn Township, Pennsylvania, in Lycoming County
- Hepburn (band), a British pop rock band
- Hepburn Act of 1906, giving the US Interstate Commerce Commission the power to set railroad rates
- Hepburn Avenue, a road in Perth, Western Australia
- Hepburn Block, an office building in Toronto, Ontario
- Hepburn romanization, a method for transcribing Japanese into the Latin alphabet.
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