|Born||21 October 1921|
|Died||21 March 2021(aged 99)|
|Nationality||British of Austrian origin|
|Education||Fitzwilliam College, Cambridge (Ph.D. 1947)|
|Awards||Fellow of the Royal Society|
|Fields||Proteolyic enzymes, fast reaction kinetics|
|Institutions||National Institute for Research in Dairying, Shinfield, Berkshire; University of Bristol|
Early life and education
Gutfreund was born on 21 October 1921 in Vienna to a middle-class professional family, the son of Clara (Pisko) and Paul Gutfreund. His father was a civil engineer, and on his mother's side there were several scientists including the physicist Karl Weissenberg. He had all his early education in Vienna. However, the political turmoil of the 1930s forced him to leave Austria for England after the Anschluss of 1938. He joined an agricultural training scheme and became an accomplished dairyman. His interest in physiology was stimulated by reading Principles of General Physiology by William Bayliss and he was much influenced by it. He earned his doctorate at Fitzwilliam College, Cambridge in 1947.
After several years at the National Institute for Research in Dairying in Shinfield, Berkshire, Gutfreund spent most of his career at the University of Bristol, where he worked on proteolytic enzymes, including chymotrypsin and trypsin, and was especially active in using methods of studying fast reactions to study enzyme mechanisms. In this connection he developed and improved apparatus for that purpose. He opposed the notion of metabolite channelling in glycolysis.
Gutfreund is also known for his textbooks on various aspects of enzyme catalysis:
- An Introduction to the Study of Enzymes.
- Enzymes: Physical Principles.
- Biochemical Evolution.
- Biothermodynamics: The Study of Biochemical Processes at Equilibrium. with John Edsall
- Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts.
- "Nobel Prizes and Fellowships - About the University". Bris.ac.uk. University of Bristol. Retrieved 1 November 2018.
- Births, marriages and deaths, March 27, 2021 – Gutfreund Professor Herbert (Freddie) Gutfreund FRS
- The International Who's Who: 1992-93. 1992. ISBN 9780946653843.
- Gutfreund, H. I was lucky, I was there at the right time. CMLS, Cell. Mol. Life Sci. 61, 1–3 (2004). https://doi.org/10.1007/s00018-003-3378-z
- Gutfreund, Herbert (2007). "How I Became a Biochemist: An Honorary One!". IUBMB Life. 59 (11): 734–737. doi:10.1080/15216540701551775. PMID 17852567. S2CID 27847114.
- Bayliss, William Maddock (1918). Principles of general physiology. London: Longmans Green & Co.
- Gutfreund, H.; Sturtevant, J. M. (1956). "The Mechanism of Chymotrypsin-Catalyzed Reactions". Proceedings of the National Academy of Sciences. 42 (10): 719–728. Bibcode:1956PNAS...42..719G. doi:10.1073/pnas.42.10.719. PMC 528322. PMID 16589938.
- Gutfreund H (1999). "Rapid-flow techniques and their contributions to enzymology". Trends in Biochemical Sciences. 24: 458–460.
- Gutfreund H, Chock PB (1991). "Substrate channelling among glycolytic enzymes: fact or fiction". Journal of Theoretical Biology. 152 (1): 117–121. Bibcode:1991JThBi.152..117G. doi:10.1016/S0022-5193(05)80524-7. PMID 1753754.
- Gutfreund, Herbert (1965). An Introduction to the Study of Enzymes. Blackwell Scientific Publications.
- Gutfreund, Herbert (1972). Enzymes: Physical Principles. Wiley-Blackwell. ISBN 0471337153.
- Gutfreund H, ed. (1981). Biochemical Evolution. Cambridge University Press. ISBN 0521280257.
- Edsall, John; Gutfreund, Herbert (1983). Biothermodynamics: The Study of Biochemical Processes at Equilibrium. Wiley-Blackwell. ISBN 0471102571.
- Gutfreund, Herbert (1995). Kinetics for the Life Sciences: Receptors, Transmitters and Catalysts. Cambridge University Press. ISBN 0521480272.
- "Herbert Gutfreund". Royal Society. Retrieved 22 January 2022.
- Bennett, Nigel G.; Gutfreund, Herbert (1 September 1973). "The kinetics of interconversion of intermediates of the reaction of pig muscle lactate dehydrogenase with oxidized nicotinamide–adenine dinucleotide and lactate". Biochemical Journal. 135 (1): 81–85. doi:10.1042/bj1350081. PMC 1165791. PMID 4359923. Retrieved 1 November 2018 – via www.biochemj.org.
- Bennett, NG; Gutfreund, H (1973). "The kinetics of the interconversion of intermediates of the reaction of pig muscle lactate dehydrogenase with oxidized nicotinamide-adenine dinucleotide and lactate". Biochem. J. 135 (1): 81–5. doi:10.1042/bj1350081. PMC 1165791. PMID 4359923.
- "Biochemical Society - Honorary Members". Biochemistry.org. Retrieved 1 November 2018.