Bosetti sang her debut in Wiesbaden (1898) as "Ännchen" in Der Freischütz. In 1900, she was a member of the Vienna State Opera and from 1901 until 1924 she was a star singer with the Bavarian State Opera. In 1903, she sang the role of "Colombina" in the first performance of Le donne curiose (Ermanno Wolf-Ferrari). She appeared in most of the German opera houses as well as in the Netherlands, Belgium, London, and Russia. In 1908, she sang in Vienna as a guest in roles such as "The Queen of the Night" and "Marguerite de Valois". She recorded for G&T Recordings, Odeon, and Gramophone.