Hexylresorcinol

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Hexylresorcinol
Hexylresorcinol.svg
Hexylresorcinol-3D-balls.png
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard 100.004.780
Chemical and physical data
Formula C12H18O2
Molar mass 194.27
3D model (Jmol)
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Hexylresorcinol is an organic compound with local anaesthetic, antiseptic and anthelmintic properties.[1]

It is available for use topically on small skin infections, or as an ingredient in throat lozenges. Johnson & Johnson markets hexylresorcinol in its Neutrogena and RoC skincare products as an anti-aging cream.

A study published in Chemical Research in Toxicology [2] shows that 4-hexylresorcinol used as a food additive (E-586) exhibits some estrogenic activity, i.e. resembles action of the female sex hormone estrogen.

In one study, 4-hexylresorcinol increased the shelf life of shrimp by reducing melanosis (black spots).[3]

In mice with cancer, 4-hexylresorcinol inhibited NF-κB and extended their survival rate.[4]

References[edit]

  1. ^ O. Gisvold (1966). C. O. Wilson, O. Gisvold and R. F. Doerge, eds. Textbook of Organic Medicinal and Pharmaceutical Chemistry (5th ed.). Philadelphia: Lippincott. pp. 237–262. 
  2. ^ Amadasi, A; Mozzarelli, A; Meda, C; Maggi, A; Cozzini, P (2009). "Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach". Chem. Res. Toxicol. 22 (1): 52–63. doi:10.1021/tx800048m. PMC 2758355Freely accessible. PMID 19063592. 
  3. ^ Montero, P. (2006). "Effectiveness of Onboard Application of 4-Hexylresorcinol in Inhibiting Melanosis in Shrimp (Parapenaeus longirostris (es))". Journal of Food Science. 69: C643–C647. doi:10.1111/j.1365-2621.2004.tb09913.x. 
  4. ^ Kim, Seong-Gon (2011). "4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells". Oncology Reports.