Higashigotanda borders Kamiōsaki, Shinagawa and Shirokanedai, Minato on the north, Takanawa, Minato on the east, Kitashinagawa, Shinagawa on the southeast, Ōsaki, Shinagawa (across Meguro River) on the south, and Nishigotanda, Shinagawa (across JR Yamanote Line) on the west.
Gotanda Station is located in Higashigotanda 1-chōme.
Higashigotanda has several well-known upper-class residential districts including Shimazuyama (島津山?) and Ikedayama (池田山?), which roughly correspond to Higashigotanda 3-chōme and 5-chōme, respectively.