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High Sierra may refer to:
- High Sierra (biome), a region of California
- Sierra Nevada (U.S.), a mountain range in California also called the High Sierra or High Sierras
- High Sierra Trail, which crosses the Sierra Nevada
- macOS High Sierra, an operating system for Apple computers
- High Sierra (film), 1941
- High Sierra Format, a CD-ROM filesystem developed in 1986
- High Sierra Music Festival, held in Quincy, California since 1991
| disambiguation page lists articles associated with the title High Sierra.
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