High Sierra may refer to:
- High Sierra (biome), a region of California
- Sierra Nevada (U.S.), a mountain range in California also called the High Sierra or High Sierras
- High Sierra Trail, a hiking trail which crosses the Sierra Nevada
- High Sierra (film), a 1941 film starring Humphrey Bogart and Ida Lupino
- High Sierra Format, an early CD-ROM filesystem, developed in 1986
- High Sierra Music Festival, an annual music festival held in Quincy, California since 1991
- High Sierra Search and Rescue, a short-lived 1995 TV series
- macOS High Sierra, the fourteenth major release of the desktop operating system from Apple Inc.
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