Hippocalcin

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HPCA
Identifiers
AliasesHPCA, BDR2, DYT2, hippocalcin
External IDsOMIM: 142622 MGI: 1336200 HomoloGene: 55634 GeneCards: HPCA
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for HPCA
Genomic location for HPCA
Band1p35.1Start32,885,994 bp[1]
End32,898,441 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002143

NM_001130419
NM_010471
NM_001286081
NM_001286083

RefSeq (protein)

NP_002134

NP_001123891
NP_001273010
NP_001273012
NP_034601

Location (UCSC)Chr 1: 32.89 – 32.9 MbChr 4: 129.11 – 129.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hippocalcin is a protein that in humans is encoded by the HPCA gene.[5][6]

Hippocalcin is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family of proteins.[7][8] It is expressed in mammalian brains especially in the hippocampus. It possesses a Ca2+/myristoyl switch.[9]

Processes[edit]

Hippocalcin takes part in the following processes:

Interactions[edit]

Hippocalcin interacts with following proteins:

  • Neuronal apoptosis inhibitory protein (NAIP)
  • Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
  • The b2 adaptin of the AP2 complex
  • Calcium-dependent activator protein for secretion (CADPS)

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121905 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028785 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. doi:10.1006/bbrc.1994.1491. PMID 8166736.
  6. ^ Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene. 225 (1–2): 117–24. doi:10.1016/S0378-1119(98)00526-5. PMID 9931466.
  7. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.
  8. ^ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. doi:10.1016/j.tins.2004.01.010. PMID 15046879.
  9. ^ O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. doi:10.1083/jcb.200306042. PMC 2173692. PMID 14638856.

Further reading[edit]

External links[edit]