Histamine N-methyltransferase

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HNMT
Histamine n-methyltransferase1.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHNMT, HMT, HNMT-S1, HNMT-S2, MRT51, histamine N-methyltransferase, Histamine N-methyltransferase
External IDsMGI: 2153181 HomoloGene: 5032 GeneCards: HNMT
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for HNMT
Genomic location for HNMT
Band2q22.1Start137,964,020 bp[1]
End138,016,364 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001024074
NM_001024075
NM_006895

NM_080462

RefSeq (protein)

NP_001019245
NP_001019246
NP_008826

NP_536710

Location (UCSC)Chr 2: 137.96 – 138.02 MbChr 2: 24 – 24.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
histamine N-methyltransferase
Identifiers
EC number2.1.1.8
CAS number9029-80-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Histamine N-methyltransferase (HMT, HNMT) is an enzyme that in humans is encoded by the HNMT gene.[5]

Histamine N-methyltransferase is one of two enzymes involved in the metabolism of histamine, the other being diamine oxidase. Histamine N-methyltransferase catalyzes the methylation of histamine in the presence of S-adenosylmethionine (SAM) forming N-methylhistamine. HMT is present in most body tissues but is not present in serum.[6] Histamine N-methyltransferase is encoded by a single gene which has been mapped to chromosome 2.

Function[edit]

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150540 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026986 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: Histamine N-methyltransferase".
  6. ^ Brown DD, Tomchick R, Axelrod J (November 1959). "The distribution and properties of a histamine-methylating enzyme" (pdf). J. Biol. Chem. 234 (11): 2948–50. PMID 13804910.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.