From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

Histatins are antimicrobial proteins found in saliva.[1]


Histatins are antimicrobial and antifungal proteins, and have been found to play a role in wound-closure.[2][3] A significant source of histatins is found in the serous fluid secreted by Ebner's glands, salivary glands at the back of the tongue. Here they offer some early defense against incoming microbes.[4]

The three major histatins are 1, 3, and 5. Histatin 2 is a degradation product of histatin 1, and all other histatins are degradation products of histatin 3. Therefore there are only two genes, HTN1 and HTN3.

Histatins also precipitate tannins from solution - thus preventing alimentary adsorption.[5]


  1. ^ Histatins at the US National Library of Medicine Medical Subject Headings (MeSH)
  2. ^ http://eprints.nuim.ie/354/
  3. ^ abstract
  4. ^ Piludu M, Lantini MS et al. "Salivary histatins in human deep posterior lingual glands (of Ebner)". Arch Biol 2006 Nov; 51(11) PMID 16859632
  5. ^ Salivary proteins as a defense against dietary tannins. Shimada T. Journal of Chemical Ecology 2006 Jun;32(6):1149-63.